Cell Engineering Of Human Bone: Effect of Transforming Growth Factor Beta (TGF-β) on Wound Healing of Bone - Couverture souple

Sefat, Farshid

 
9783639516746: Cell Engineering Of Human Bone: Effect of Transforming Growth Factor Beta (TGF-β) on Wound Healing of Bone
Couverture souple
ISBN 10 : 3639516745 ISBN 13 : 9783639516746
Editeur : Scholars' Press, 2013

Synopsis

Bone repair is modulated by different stimuli. There is evidence that the Transforming Growth Factor-beta (TGF-β) super-family of cytokines have significant effects on bone structure by regulating the replication and differentiation of chondrocytes, osteoblasts and osteoclasts. This book aimed at determining the role of the TGF-βs, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG-63 bone cells were used to examine cell adhesion and alignment to different micro-contact printed ECM protein patterns of different widths. The study also aimed at examining how various TGF-β isomers (TGF-β1, 2 and 3) and their solvent and carrier (HCl and BSA, respectively) effected cell surface interactions, cell morphology, cell proliferation and integrin expression. Finally, this study also aimed at examining how the TGF-βs and their solvent and carrier influenced wound closure in an in vitro wound closure model and how TGF-βs influence ECM secretion and integrin expression.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Bone repair is modulated by different stimuli. There is evidence that the Transforming Growth Factor-beta (TGF-β) super-family of cytokines have significant effects on bone structure by regulating the replication and differentiation of chondrocytes, osteoblasts and osteoclasts. This book aimed at determining the role of the TGF-βs, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG-63 bone cells were used to examine cell adhesion and alignment to different micro-contact printed ECM protein patterns of different widths. The study also aimed at examining how various TGF-β isomers (TGF-β1, 2 and 3) and their solvent and carrier (HCl and BSA, respectively) effected cell surface interactions, cell morphology, cell proliferation and integrin expression. Finally, this study also aimed at examining how the TGF-βs and their solvent and carrier influenced wound closure in an in vitro wound closure model and how TGF-βs influence ECM secretion and integrin expression.

Biographie de l'auteur

Dr. Farshid Sefat is a Post Doctorate Research Assistant at the University of Sheffield (United Kingdom). He received his bachelor degree in Medical Engineering from University of Bradford (UK), MSc. in Cell and Tissue Engineering from Keele University (UK) and PhD in Bone Tissue Engineering from University of Bradford (UK).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Scholars' Press
Date d'édition
2013
Langue
anglais
ISBN 10 
3639516745
ISBN 13 
9783639516746
Reliure
Broché
Nombre de pages
236
Coordonnées du fabricant
non disponible
Personne responsable
non disponible