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Free Radical Mediated Injury During Coronary Artery By-pass Surgery: Time course of Free radical generation and the role of antioxidants during CABGS - Couverture souple

Movahed, Ali

 
9783639519907: Free Radical Mediated Injury During Coronary Artery By-pass Surgery: Time course of Free radical generation and the role of antioxidants during CABGS
Couverture souple
ISBN 10 : 3639519906 ISBN 13 : 9783639519907
Editeur : Scholars' Press, 2013

Synopsis

Free- radicals are generated in the minutes following myocardial re-perfusion and this could be the cause of myocardial injury during by Pass surgery. Pretreatment with antioxidants could effectively attenuate re-perfusion injury during global ischemia.Xanthine dehydrogenase is converted into xanthine oxidase and this causes accumulation of hypoxanthine and xanthine in the cell. When re-perfusion starts, fresh oxygen interacts with xanthine oxidane and hypoxanthine to form superoxide anion radical O2.- . Allopurinol can metabolically block the formation of reduced oxygen radical by inhibiting the enzyme xanthine oxidase. More over allopurinal has vasodilator effects and aids in restoring favorable conditions through enhancement of collateral blood flow to the ischemic area.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Free- radicals are generated in the minutes following myocardial re-perfusion and this could be the cause of myocardial injury during by Pass surgery. Pretreatment with antioxidants could effectively attenuate re-perfusion injury during global ischemia.Xanthine dehydrogenase is converted into xanthine oxidase and this causes accumulation of hypoxanthine and xanthine in the cell. When re-perfusion starts, fresh oxygen interacts with xanthine oxidane and hypoxanthine to form superoxide anion radical O2.- . Allopurinol can metabolically block the formation of reduced oxygen radical by inhibiting the enzyme xanthine oxidase. More over allopurinal has vasodilator effects and aids in restoring favorable conditions through enhancement of collateral blood flow to the ischemic area.

Biographie de l'auteur

I am an Associate professor and Head of Department of Clinical Biochemistry in the Faculty of medicine at Bushehr University of Medical and Biological Sciences, Bushehr, Iran.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Scholars' Press
Date d'édition
2013
Langue
anglais
ISBN 10 
3639519906
ISBN 13 
9783639519907
Reliure
Broché
Nombre de pages
104
Éditeur
Ashavaid Tester, Netticadan Thomas
Coordonnées du fabricant
non disponible
Personne responsable
non disponible