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Alterations in Mammary Epithelial Cell Identity: Potential Tools for Breast Cancer Risk Assessment and Prevention - Couverture souple

Coradini, Danila; Oriana, Saro

 
9783639656244: Alterations in Mammary Epithelial Cell Identity: Potential Tools for Breast Cancer Risk Assessment and Prevention
Couverture souple
ISBN 10 : 3639656245 ISBN 13 : 9783639656244
Editeur : Edizioni Accademiche Italiane, 2014

Synopsis

In the next future, cancer prevention will be the main concern. Therefore, elucidating the molecular mechanisms that, if altered, may trigger the neoplastic transformation of the cells that form human mammary gland, is crucial to prevent breast cancer, the leading cause of cancer death in women. Growing evidences indicate that the epigenetic control of gene expression plays a key role in the homeostasis of the mammary tissue, and suggest that alterations in this control can affect the identity of the epithelial cells and trigger their transformation. Since, unlike genetic alterations, epigenetic changes are potentially reversible, a better understanding of the mechanisms that regulate the establishment and maintenance of cell identity can provide valuable information to develop innovative strategies for cancer prevention aimed at reverting epigenome dysfunctions and hindering tumorigenesis. In this book, after describing the biological basis of cell identity establishment and maintenance, the authors discuss the effects of cell identity disruption in two different benign lesions and propose some interesting epigenome-targeting strategies potentially useful for cancer prevention.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In the next future, cancer prevention will be the main concern. Therefore, elucidating the molecular mechanisms that, if altered, may trigger the neoplastic transformation of the cells that form human mammary gland, is crucial to prevent breast cancer, the leading cause of cancer death in women. Growing evidences indicate that the epigenetic control of gene expression plays a key role in the homeostasis of the mammary tissue, and suggest that alterations in this control can affect the identity of the epithelial cells and trigger their transformation. Since, unlike genetic alterations, epigenetic changes are potentially reversible, a better understanding of the mechanisms that regulate the establishment and maintenance of cell identity can provide valuable information to develop innovative strategies for cancer prevention aimed at reverting epigenome dysfunctions and hindering tumorigenesis. In this book, after describing the biological basis of cell identity establishment and maintenance, the authors discuss the effects of cell identity disruption in two different benign lesions and propose some interesting epigenome-targeting strategies potentially useful for cancer prevention.

Biographie de l'auteur

Danila Coradini, PhD, and Saro Oriana, MD, collaborate on breast cancer research since the eighties when they worked together respectively as biologist and clinician at the National Cancer Institute of Milan. Currently, DC collaborates with the University of Milan and SO is director of the Senology Center at the Ambrosiana Clinic in Cesano Boscone.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Edizioni Accademiche Italiane
Date d'édition
2014
Langue
anglais
ISBN 10 
3639656245
ISBN 13 
9783639656244
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
non disponible