Signal Transduction: Pathways, Mechanisms and Diseases - Couverture rigide

Couverture rigide

ISBN 10 : 3642021115 ISBN 13 : 9783642021114

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2009

Synopsis

Anotherareacoveredinthisbook, onenotoftenhighlightedinsignaltransd- tionbooks, isthatofsignalingplatforms, whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism, cellproliferation, differentiation, apop- sis, neurodegenerativediseases, andcancer. Theauthorscontributingtothisbook vii viii Preface areexpertsandactivecontributorstoresearchintheirspeci?careasofsignaling. I would like to thank them for their contributions and their suggestions in the developmentofthebook. IwouldliketoacknowledgethehelpofFrankTedeschi, astudentinmydepartment, whoassistedineditingthemanuscriptsandinprep- ingtheindex. IwouldalsoliketothankDr. SabineSchwarz, LifeSciencesEditorat SpringerVerlag, andDr. JuttaLindenbornwhohavebeenveryhelpfulatevery stageofproductionofthisbook. AriSitaramayya Contents PartI GProteinsandGProtein CoupledReceptors 1 TraditionalGPCRPharmacologyandBeyond. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AnnetteGilchristandMariaR. Mazzoni 2 RegulationofIntraneuronalTraf?ckingofG-Protein-Coupled ReceptorsbyNeurotransmittersInVivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 VeroniqueBernard 3 SmallGTPasesandTheirRoleinRegulatingGProtein-Coupled ReceptorSignalTransduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 FabiolaM. RibeiroandStephenS. G. Ferguson 4 RegulationofGProteinReceptorCoupling, MoodDisorders andMechanismofActionofAntidepressants . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 MoranGolan, GabrielSchreiber, andSo?aAvissar 5 DysregulationofGProtein-CoupledReceptorSignaling inCancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 JoAnnTrejo PartII GrowthFactors 6 InsulinSignalinginNormalandDiabeticConditions . . . . . . . . . . . . . . . . . 101 PatriceEFort, HisanoriImai, RajuRajala, andThomasW. Gardner 7 EpidermalGrowthFactor(EGF)ReceptorSignaling andCancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 ElizabethS. HensonandSpencerB. Gibson ix x Contents 8 LeptinSignalingPathway. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 HiroyukiShimizu 9 SignalinginNormalandPathologicalAngiogenesis. . . . . . . . . . . . . . . . . . 159 MichaelR. MancusoandCalvinJ. Kuo PartIII SignalingPlatforms 10 SpatialandTemporalControlofCellSignaling byA-KinaseAnchoringProteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 F. DonelsonSmith, LoreneK. Langeberg, andJohnD. Scott 11 Mitochondria, aPlatformforDiverseSignalingPathways . . . . . . . . . . 199 AstridC. SchaussandHeidiM. McBridee 12 Mitogen-ActivatedProteinKinases andTheirScaffoldingProteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 DannyN. DhanasekaranandE. PremkumarReddy 2 13 MolecularandFunctionalDeterminantsofCa SignalingMicrodomains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 InduS. Ambudkar, HweiL. Ong, andBrijB. Singh PartIV NuclearReceptors/Transcription 14 EukaryoticGeneTranscription . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 JenniferH. GromekandArikDvir 15 EstrogenSignalingMechanisms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 DapengZhangandVanceL. Trudeau 16 SignalTransductionPathwaysInvolved inGlucocorticoidActions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 PeterJ. Barnes PartV ReactiveSignalingMolecules 17 CellularSignalingbyReactiveOxygenSpecies: Biochemical BasisandPhysiologicalScope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 MichelB. Toledano, SimonFourquet, andBeno?tD Autreaux 18 SolubleGuanylylCyclase: TheNitricOxideReceptor. . . . . . . . . . . . . . . 337 DorisKoeslingandAriSitaramayya Contents xi PartVI CellCycle, CellDeathandCancer 19 DistinctRolesofthePocketProteinsintheControl ofCellCycle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 353 ParaskeviVogiatziandPierPaoloClaudio 20 Activationofthep53TumorSuppressoranditsMultipleRoles inCellCycleandApoptosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375 LucianaE. GionoandJamesJ. Manfredi 21 AgingandCancer: CaretakersandGatekeepers . . . . . . . . . . . . . . . . . . . . . 397 DianavanHeemst 22 SignalTransductioninEmbryonicStemCells andtheRiseofiPSCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

A propos du livre

Présentation de l'éditeur

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2009
• Langue: anglais
• ISBN 10: 3642021115
• ISBN 13: 9783642021114
• Reliure: Relié
• Nombre de pages: 448
• Éditeur: Sitaramayya Ari
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne