Articles liés à Immunological Synapses
Immunological Synapses - Couverture rigide
Livre 52 sur 258: Current Topics in Microbiology and Immunology
Synopsis
The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide-MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide-MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide- MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.
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Immune Synapses (eng)
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Immunological Synapse
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Springer Berlin Heidelberg, Springer Berlin Heidelberg Dez 2009, 2009
ISBN 10 : 3642038573
ISBN 13 : 9783642038570
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci c peptide-MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide-MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide- MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the delity of the response. 272 pp. Englisch. N° de réf. du vendeur 9783642038570
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Immunological Synapse
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Springer Berlin Heidelberg, 2009
ISBN 10 : 3642038573
ISBN 13 : 9783642038570
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Includes supplementary material: sn.pub/extrasThe proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow a. N° de réf. du vendeur 5044130
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Immunological Synapse (Current Topics in Microbiology and Immunology, 340)
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Immunological Synapse
Edité par
Springer Berlin Heidelberg, Springer Berlin Heidelberg Dez 2009, 2009
ISBN 10 : 3642038573
ISBN 13 : 9783642038570
Neuf
Couverture rigide
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci c peptide¿MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide¿MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide¿ MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the delity of the response.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch. N° de réf. du vendeur 9783642038570
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Immunological Synapse
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Springer, 2009
ISBN 10 : 3642038573
ISBN 13 : 9783642038570
Ancien ou d'occasion
Couverture rigide
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Etat : Sehr gut. Zustand: Sehr gut | Seiten: 272 | Sprache: Englisch | Produktart: Bücher | The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide¿MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide¿MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide¿ MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response. N° de réf. du vendeur 5672788/12
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Immunological Synapses: Vol 340
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Immunological Synapse
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Buch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci c peptide-MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide-MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide- MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the delity of the response. N° de réf. du vendeur 9783642038570
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