CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential - Couverture souple
Livre 9 sur 258: Current Topics in Microbiology and Immunology
Synopsis
Preface.- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides.- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology.- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That 'Isolates' Repertoires Undergoing Positive or Negative Selection.- Selection and Behaviour of CD4+CD25+ T Cells in vivo: Lessons from T Cell Receptor Transgenic Models.- Migration Matters: Functional Properties of Naïve- and Effector/Memory-Like Regulatory T Cell Subsets.- Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells.- Dendritic Cells, Key Cells for the Induction of Regulatory T Cells?.- Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study or CD4+CD25+ T Cell-Mediated Suppresion.- Regulatory T Cells in Experimental Colitis.- Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: the Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control.- Regulatory T Cells in Transplantation Tolerance. Infectious Tolerance.- CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation.- ..................- Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells.- Subject Index.
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential (eng)
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
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Springer Berlin Heidelberg, 2010
ISBN 10 : 3642063764
ISBN 13 : 9783642063763
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Preface.- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides.- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology.- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Re. N° de réf. du vendeur 5045487
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
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Springer Berlin Heidelberg Okt 2010, 2010
ISBN 10 : 3642063764
ISBN 13 : 9783642063763
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called 'natural' regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action. 344 pp. Englisch. N° de réf. du vendeur 9783642063763
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential (Current Topics in Microbiology and Immunology, 293)
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential (Current Topics in Microbiology and Immunology, 293)
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
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Taschenbuch. Etat : Neu. CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential | Elisabeth Suri-Payer (u. a.) | Taschenbuch | xii | Englisch | 2010 | Springer-Verlag GmbH | EAN 9783642063763 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 107038351
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Edité par
Springer Berlin Heidelberg, Springer Berlin Heidelberg Okt 2010, 2010
ISBN 10 : 3642063764
ISBN 13 : 9783642063763
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -yetwehopethatitwillofferinspirationandorientationtothescientistwho wouldliketoenterthis eld. To date, many different cells have been described that can suppress + + other cells of the immune system: CD4 CD25 regulatory T cells (Treg), + CD4 CD25 regulatory T cells, T regulatory 1 cells (Tr1), T-helper 3 cells + (Th3),CD8 CD28 Tcells,NKTcells,aswellastolerogenicdendriticcells. Suppressive CD4 T cells fall at least into two categories. So called natural VI Preface + + CD4 CD25 Tregformpartoftheintra-thymicallyselectedTcellrepertoire andapparentlyconstituteadistinctlineage. Incontrast,¿adaptive¿regulatory Tcellsareinstructedintheperipherytobecomesuppressivecells,theyform + + amoreheterogeneousgroupincludingCD4 CD25 Treg,Tr1,andTh3cells. As natural Treg are so far the best characterized entity, the rst three contributionsofthisvolume(C. Cozzoetal. ,C. -S. Hsiehetal. ,andL.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 344 pp. Englisch. N° de réf. du vendeur 9783642063763
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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Edité par
Springer Berlin Heidelberg, Springer Berlin Heidelberg, 2010
ISBN 10 : 3642063764
ISBN 13 : 9783642063763
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called 'natural' regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action. N° de réf. du vendeur 9783642063763
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Cd4+cd25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
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