Alternative Splicing and Disease - Couverture souple

Livre 6 sur 31: Progress in Molecular and Subcellular Biology
 
9783642070815: Alternative Splicing and Disease

Synopsis

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

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Autres éditions populaires du même titre

9783540344483: Alternative Splicing And Disease

Edition présentée

ISBN 10 :  3540344489 ISBN 13 :  9783540344483
Editeur : Springer-Verlag Berlin and Heide..., 2006
Couverture rigide