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9783642071836: Glycopeptides and Glycoproteins: Synthesis, Structure, and Application

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ISBN 10 : 364207183X ISBN 13 : 9783642071836

Editeur : Springer, 2010

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With contributions by numerous experts

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�diteur: Springer
Date d'�dition: 2010
Langue: anglais
ISBN 10: 364207183X
ISBN 13: 9783642071836
Reliure: Broch�
Num�ro d'�dition: 1
Nombre de pages: 280
�diteur: Wittmann Valentin
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Glycopeptides and Glycoproteins (eng)

Wittmann, Valentin

Edit� par Springer, 2010

ISBN 10 : 364207183X ISBN 13 : 9783642071836

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Glycopeptides and Glycoproteins

Wittmann, Valentin

Edit� par Springer Berlin Heidelberg, 2010

ISBN 10 : 364207183X ISBN 13 : 9783642071836

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. With contributions by numerous experts|This series presents critical reviews of the present position and future trends in modern chemical researchShort and concise reports on chemistry, each written by the world renowned expertsStill valid . N� de r�f. du vendeur 5046262

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Glycopeptides and Glycoproteins

Valentin Wittmann

Edit� par Springer Berlin Heidelberg Nov 2010, 2010

ISBN 10 : 364207183X ISBN 13 : 9783642071836

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the last 50 years molecular biology was dominated by the exploration of proteins and nucleic acids. Beside their role in energy metabolism, oligos- charides,which represent thethirdclass ofbiomacromolecules, have received less attention. Today it is well established that oligosaccharides are involved in many important biologicalregulation and recognition processes fromp- tein folding to cell cell communication. Glycosylation of proteins is the most complexformofco-andposttranslationalmodi cation. Thedeterminationof structure-function relationships, however, remains dif cult due to the mic- heterogeneity of glycoproteins that exist in many different glycoforms. Thus chemical synthesis of glycoproteins and glycopeptides with de ned glycan structures plays a pivotal role for the detailed determination of the role of protein glycosylation. This topic is covered by the rst two chapters of this bookdealingwiththechemicaland enzymatic synthesis ofglycopeptides and glycoproteins. The third chapter describes the construction of glycopeptide andglycoproteinmimetics containingnon-naturalstructuralelements. These so-calledneoglycopeptidesandneoglycoproteins,respectively,canprovide- sight on the importance of distinct structural elements on biological activity andmayhaveimproved propertiessuchasanincreased stability. Theappli- tion of synthetic glycopeptides, in many cases at the clinical level, as vaccines forbothcancerandHIVisthesubjectofthefourthchapter. Glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are synthesized by non-ribosomal peptide synthetases. Some of them serve as antibiotics of last resort in the treatment of nosocomial infections with enterococci and methicillin-resistant Staphylococcus aureus (MRSA) strains. Their structure, biosynthesis, and mode of action are summarized in the fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling. 280 pp. Englisch. N� de r�f. du vendeur 9783642071836

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Glycopeptides and Glycoproteins | Synthesis, Structure, and Application

Valentin Wittmann

Edit� par Springer, 2010

ISBN 10 : 364207183X ISBN 13 : 9783642071836

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Glycopeptides and Glycoproteins

Valentin Wittmann

Edit� par Springer Berlin Heidelberg, Springer Nov 2010, 2010

ISBN 10 : 364207183X ISBN 13 : 9783642071836

Neuf Taschenbuch

impression � la demande

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Their structure, biosynthesis, and mode of action are summarized in the fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch. N� de r�f. du vendeur 9783642071836

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Glycopeptides and Glycoproteins : Synthesis, Structure, and Application

Valentin Wittmann

Edit� par Springer Spektrum, 2010

ISBN 10 : 364207183X ISBN 13 : 9783642071836

Neuf Taschenbuch

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

�valuation du vendeur 5 sur 5 �toiles

Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - In the last 50 years molecular biology was dominated by the exploration of proteins and nucleic acids. Beside their role in energy metabolism, oligos- charides,which represent thethirdclass ofbiomacromolecules, have received less attention. Today it is well established that oligosaccharides are involved in many important biologicalregulation and recognition processes fromp- tein folding to cell cell communication. Glycosylation of proteins is the most complexformofco-andposttranslationalmodi cation. Thedeterminationof structure-function relationships, however, remains dif cult due to the mic- heterogeneity of glycoproteins that exist in many different glycoforms. Thus chemical synthesis of glycoproteins and glycopeptides with de ned glycan structures plays a pivotal role for the detailed determination of the role of protein glycosylation. This topic is covered by the rst two chapters of this bookdealingwiththechemicaland enzymatic synthesis ofglycopeptides and glycoproteins. The third chapter describes the construction of glycopeptide andglycoproteinmimetics containingnon-naturalstructuralelements. These so-calledneoglycopeptidesandneoglycoproteins,respectively,canprovide- sight on the importance of distinct structural elements on biological activity andmayhaveimproved propertiessuchasanincreased stability. Theappli- tion of synthetic glycopeptides, in many cases at the clinical level, as vaccines forbothcancerandHIVisthesubjectofthefourthchapter. Glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are synthesized by non-ribosomal peptide synthetases. Some of them serve as antibiotics of last resort in the treatment of nosocomial infections with enterococci and methicillin-resistant Staphylococcus aureus (MRSA) strains. Their structure, biosynthesis, and mode of action are summarized in the fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling. N� de r�f. du vendeur 9783642071836

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