Targeting Functional Centers of the Ribosome - Couverture souple

Davidovich, Chen

Couverture souple

ISBN 10 : 364226705X ISBN 13 : 9783642267055

Editeur : Springer, 2013

Synopsis

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

A propos du livre

Présentation de l'éditeur

Targeting Functional Centers of the Ribosome investigates the mode of function, inhibition, and evolution of the Peptidyl Transferase Center (PTC) by a combination of X-ray crystallography, biochemistry, molecular biology and theoretical studies.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 364226705X
• ISBN 13: 9783642267055
• Reliure: Broché
• Nombre de pages: 88
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne