Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Art Petronis and Jon Mill s research is dedicated to the understanding of the role of epigenetic risk factors in complex diseasesEpigenetic processes can explain some of the epidemiological associations between environmental exposure and disease,. N° de réf. du vendeur 5054876
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases. 336 pp. Englisch. N° de réf. du vendeur 9783642268328
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Taschenbuch. Etat : Neu. Brain, Behavior and Epigenetics | Jonathan Mill (u. a.) | Taschenbuch | xvi | Englisch | 2013 | Springer-Verlag GmbH | EAN 9783642268328 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 105734329
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -InhaltsangabePreface.-1. Post-translational histone modifications and the neurobiology of psychosis.- 2. Epigenetic regulation of GABAergic targets in psychiatry.- 3. Possible roles of DNA methylation in bipolar disorder.- 4. The epigenetics of depression and suicide.- 5. Epidemiology research and epigenetics: Translational epidemiology of schizophrenia.-6. Environmental studies as a tool for detecting epigenetic mechanisms in schizophrenia.-7. Imprinting, inactivation and the behavioural genetics of the X-chromosome.-8. The strategies of the genes: genomic conflicts, attachment theory and development of the social brain.- 9. Genomic imprinting effects on brain and behavior; future directions.- 10. Epigenetic influence of the social environment.- 11. Towards an understanding of the dynamic inter-dependence of genes and environment in the regulation of phenotype. Nurturing our epigenetic nature.-12. Histone deacetylase inhibitors: a novel therapeutic approach for cognitive disorders.-13. Epigenetic mechanisms of memory consolidation.- 14. Epigenetic mechanisms in memory formation.- Subject index.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch. N° de réf. du vendeur 9783642268328
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases. N° de réf. du vendeur 9783642268328
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