Epigenetic Therapy of Cancer: Preclinical Models and Treatment Approaches - Couverture rigide

Couverture rigide

ISBN 10 : 364238403X ISBN 13 : 9783642384035

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2014

Synopsis

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

A propos du livre

Présentation de l'éditeur

This book covers the translation of basic research and drug development to clinical applications in the treatment of solid tumors as well as hematologic malignancies and hemoglobinopathy. It examines both present and future clinical strategies.

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2014
• Langue: anglais
• ISBN 10: 364238403X
• ISBN 13: 9783642384035
• Reliure: Relié
• Nombre de pages: 335
• Éditeur: Lübbert Michael, Jones Peter A.
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne