Cell Polarity and Subcellular RNA Localization - Couverture souple
Livre 38 sur 66: Results and Problems in Cell Differentiation
Synopsis
Localization of mRNAs at Synaptic Sites on Dendrites.- 1 Introduction.- 2 The Machinery for Translation in Dendrites.- 2.1 SPRCs Are Precisely Localized in the Postsynaptic Cytoplasm.- 2.2 SPRCs Are Present at Spine Synapses on Different Neuron Types.- 2.3 SPRCs Are Often Associated with Membranous Organelles in an RER-Like Configuration.- 2.4 SPRCs Are Also Present at Non-Spine Synapses.- 2.5 SPRCs Are Especially Prominent at Developing Synapses.- 3 Types of Proteins That Are Synthesized at SPRCs.- 3.1 Biochemical Studies of Proteins Synthesized by Subcellular Fractions Enriched in Pinched-Off Dendrites.- 3.2 mRNAs in the Dendrites of Neurons in Vivo.- 3.3 Molecular Biological Analyses of the Complement of mRNAs in Isolated Dendrites from Neurons in Vitro.- 3.4 The Search for Novel Dendritic mRNAs.- 4 Activity-Dependent Regulation of mRNA Trafficking in Dendrites.- 4.1 Lessons from the Study of Arc: A Cellular Mechanism for Protein Synthesis-Dependent Synaptic Modification.- 4.2 Post-Translational Processing Within Dendrites.- 5 Signals That Mediate mRNA Routing and Localization.- 5.1 Granules: Supramolecular Packets That May Be Involved in mRNA Transport.- 5.2 mRNA Translocation Mechanisms.- 5.3 Regulation of mRNA Translation at Synapses.- 5.3.1 Studies in Hippocampal Slices 20 5.3.2 Studies in Intact Animals 20 5.3.3 Studies in Synaptoneurosomes.- 6 Conclusion.- References.- Long-Lasting Hippocampal Plasticity: Cellular Model for Memory Consolidation?.- 1 Introduction.- 2 How?.- 2.1 Long-Term Potentiation.- 2.2 Synaptic Tagging and the Variable Persistence of Hippocampal Synaptic Plasticity.- 2.3 Requirements for Cellular Consolidation.- 3 Where?.- 4 When?.- 5 Conclusion.- References.- Neuronal RNA Localization and the Cytoskeleton.- 1 Localization of Cytoskeletal Proteins to Neuronal Processes and Growth Cones.- 2 Regulation of Neuronal mRNA Localization.- 3 Mechanism of mRNA Localization.- 4 mRNA May Be Transported as Particles or Granules.- 5 Future Directions.- References.- Transcription Factors in Dendrites: Dendritic Imprinting of the Cellular Nucleus.- 1 Introduction.- 2 CREB mRNA Is Localized to Neuronal Dendrites.- 3 CREB Protein Is Present in Dendrites.- 4 CREB Protein Moves from the Dendrite to the Cell Nucleus.- 5 Potential Importance of Dendritic CREB in Modulating.- Neuronal Functioning.- 6 Biological Impetus tor Dendritic Imprinting.- References.- RNA Trafficking in Oligodendrocytes.- 1 Introduction.- 2 A2RE Is a cis-Acting RNA Trafficking Determinant.- 3 hnRNP A2 Is a trans-Acting RNA Trafficking Factor.- 4 A2RE/hnRNP A2-Mediated Nuclear Export.- 5 A2RE/hnRNP A2-Mediated Granule Assembly.- 6 A Dual Motor Mechanism for RNA Trafficking on Microtubules.- 7 RNA Trafficking in the Virtual Cell.- 8 The Taxol Paradox.- 9 Negotiating Branch Points.- 10 Translation Regulation.- 11 Summary.- References.- Extrasomatic Targeting of MAP2, Vasopressin and Oxytocin mRNA in Mammalian Neurons.- 1 Introduction.- 2 Microtubule-Associated Protein 2.- 2.1 Dendritic Localization of MAP2 mRNAs.- 2.2 Distribution and Function of MAP2 in Neurons.- 2.3 Characterization of a cis-Acting Dendritic Targeting Element in the MAP2 3' UTR.- 3 Axonal and Dendritic Targeting of VP and OT mRNAs.- 3.1 Axonal mRNA Compartmentalization.- 3.2 Dendritic mRNA Compartmentalization.- 3.3 Molecular Determinants of Subcellular mRNA Targeting.- 4 Final Conclusions and Perspectives.- References.- RNA Transport and Local Protein Synthesis in the Dendritic Compartment.- 1 Introduction.- 2 Differential Subcellular RNA Localization in Neurons.- 2.1 Dendritic RNAs.- 2.2 Synaptic mRNAs.- 2.2.1 Neurotransmitter Receptor mRNAs.- 2.2.2 Non-Neurotransmitter Receptor Synaptic mRNAs.- 2.3 Axonal and Presynaptic mRNAs.- 3 RNA Transport.- 3.1 trans-Acting Factors.- 3.1.1 Translational Factors and Transport Granules.- 3.1.2 Granule Motors.- 3.1.3 mRNA-Specific trans-Acting Factors.- 3.2 cis-Acting Sequences.- 4 Synapse and Local Protein Synthesis Machinery.- 4.1 Ultrast
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
