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Applied Toxicology: Approaches Through Basic Science: Proceedings of the 1996 EUROTOX Congress Meeting Held in Alicante, Spain, September 22–25, 1996 - Couverture souple

 
9783642645051: Applied Toxicology: Approaches Through Basic Science: Proceedings of the 1996 EUROTOX Congress Meeting Held in Alicante, Spain, September 22–25, 1996
Couverture souple
ISBN 10 : 3642645054 ISBN 13 : 9783642645051
Editeur : Springer, 2011

Synopsis

Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).

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Éditeur
Springer
Date d'édition
2011
Langue
anglais
ISBN 10 
3642645054
ISBN 13 
9783642645051
Reliure
Broché
Nombre de pages
432
Éditeur
Seiler Jürg P., Vilanova Eugenio
Coordonnées du fabricant
non disponible
Personne responsable
CMN Printpool Inh. Mathis Neumann
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