Mechanisms of Drug Interactions - Couverture souple

Couverture souple

ISBN 10 : 3642646581 ISBN 13 : 9783642646584

Editeur : Springer, 2011

Synopsis

Over the years a number of excellent books have classified and detailed drug- drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering intestinal absorption or bioavailability; those involving hepatic metabolising enzymes; those involving competition or antagonism for receptor sites, and drug interactions modifying excretory mechanisms. Such books have presented extensive tables of interactions and their management. Although of considerable value to clinicians, such publica- tions have not, however, been so expressive about the individual mechanisms that underlie these interactions. It is within this sphere of "mechanisms" that this present volume specialises. It deals with mechanisms of in vitro and in vivo, drug-drug, drug- food and drug-herbals interactions and those that cause drugs to interfere with diagnostic laboratory tests. We believe that an explanation of the mechanisms of such interactions will enable practitioners to understand more fully the nature of the interactions and thus enable them to manage better their clinical outcome. If mechanisms of interactions are better understood, then it may be pos- sible for the researcher to develop meaningful animal/biochemical/tissue cul- ture or physicochemical models to which new molecules could be exposed during their development stages. The present position, which largely relies on patients experiencing adverse interactions before they can be established or documented, can hardly be regarded as satisfactory. This present volume is classified into two major parts; firstly, pharmacoki- netic drug interactions and, secondly, pharmacodynamic drug interactions.

A propos du livre

Présentation de l'éditeur

This book draws from leaders who are active in the various disciplines to provide a broad spectrum of information on mechanisms and clinical impact of drug interactions - of critical importance in this age of multiple-drug therapy. It deals with mechanisms of in vitro and in vivo, drug-drug, drug-food and drug-herbal interactions and those that cause drugs to interfere with diagnostic laboratory tests. It describes all aspects of drug interactions and their mechanisms ranging from those affecting drug absorption, metabolism, excretion and pharmacology and therapeutic activity, through those interactions affecting drug analysis. This volume will add much to that which is currently known about drug interactions and will directly enhance the safer use of medicines.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 3642646581
• ISBN 13: 9783642646584
• Reliure: Broché
• Nombre de pages: 384
• Éditeur: D'Arcy Patrick F., McElnay James C., Welling Peter G.
• Coordonnées du fabricant: GPSR Kontakt; ProductSafety@springernature.com; ; Tiergartenstr. 17; Heidelberg; 69121; Allemagne