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Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine - Couverture souple
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Synopsis
The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind- ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions constitute a network within the immune system. Since one lymphocyte produces only one type of antibody molecule, this network is in fact a network of cells. We expect that the network is functional: the appearance of antigen will disturb the equilibrium of the network at the point where it competes with the anti- idiotypic lymphocyte for binding to the idiotypic lympho- cyte. It has been known for quite some time that anti- idiotypic antibody can be used to prime the immune system for memory to an antigen that it has never seen. This phe- nomenon is now being explored for possible use in immuni- zation against viruses, bacteria, parasites and tumors as well as for the modulation of autoimmunity. The ability of anti-idiotypes to mimic, both antigenically and function- ally, the corresponding biologically active molecules seen by an idiotypic antibody was first demonstrated for the hormone insulin and is now being observed in many other systems. The papers assembled in this volume- bring the reader to the cutting edge of the potential practical applica- tions of the network theory of the immune system.
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Images of Biologically Active Structures in the Immune System (eng)
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Images of Biologically Active Structures in the Immune System
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Springer, Springer Nov 2011, 2011
ISBN 10 : 3642706770
ISBN 13 : 9783642706776
Neuf
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions constitute a network within the immune system. Since one lymphocyte produces only one type of antibody molecule, this network is in fact a network of cells. We expect that the network is functional: the appearance of antigen will disturb the equilibrium of the network at the point where it competes with the anti idiotypic lymphocyte for binding to the idiotypic lympho cyte. It has been known for quite some time that anti idiotypic antibody can be used to prime the immune system for memory to an antigen that it has never seen. This phe nomenon is now being explored for possible use in immuni zation against viruses, bacteria, parasites and tumors as well as for the modulation of autoimmunity. The ability of anti-idiotypes to mimic, both antigenically and function ally, the corresponding biologically active molecules seen by an idiotypic antibody was first demonstrated for the hormone insulin and is now being observed in many other systems. The papers assembled in this volume bring the reader to the cutting edge of the potential practical applica tions of the network theory of the immune system. 158 pp. Englisch. N° de réf. du vendeur 9783642706776
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Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine (Current Topics in Microbiology and Immunology, 119)
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Images of Biologically Active Structures in the Immune System
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Springer Berlin Heidelberg, 2011
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Couverture souple
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which . N° de réf. du vendeur 5068614
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Images of Biologically Active Structures in the Immune System : Their Use in Biology and Medicine
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions constitute a network within the immune system. Since one lymphocyte produces only one type of antibody molecule, this network is in fact a network of cells. We expect that the network is functional: the appearance of antigen will disturb the equilibrium of the network at the point where it competes with the anti idiotypic lymphocyte for binding to the idiotypic lympho cyte. It has been known for quite some time that anti idiotypic antibody can be used to prime the immune system for memory to an antigen that it has never seen. This phe nomenon is now being explored for possible use in immuni zation against viruses, bacteria, parasites and tumors as well as for the modulation of autoimmunity. The ability of anti-idiotypes to mimic, both antigenically and function ally, the corresponding biologically active molecules seen by an idiotypic antibody was first demonstrated for the hormone insulin and is now being observed in many other systems. The papers assembled in this volume bring the reader to the cutting edge of the potential practical applica tions of the network theory of the immune system. N° de réf. du vendeur 9783642706776
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Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine (Current Topics in Microbiology and Immunology)
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Springer Berlin Heidelberg, 2012
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ISBN 13 : 9783642706776
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Images of Biologically Active Structures in the Immune System
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Springer, Springer Vieweg Nov 2011, 2011
ISBN 10 : 3642706770
ISBN 13 : 9783642706776
Neuf
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions constitute a network within the immune system. Since one lymphocyte produces only one type of antibody molecule, this network is in fact a network of cells. We expect that the network is functional: the appearance of antigen will disturb the equilibrium of the network at the point where it competes with the anti idiotypic lymphocyte for binding to the idiotypic lympho cyte. It has been known for quite some time that anti idiotypic antibody can be used to prime the immune system for memory to an antigen that it has never seen. This phe nomenon is now being explored for possible use in immuni zation against viruses, bacteria, parasites and tumors as well as for the modulation of autoimmunity. The ability of anti-idiotypes to mimic, both antigenically and function ally, the corresponding biologically active molecules seen by an idiotypic antibody was first demonstrated for the hormone insulin and is now being observed in many other systems. The papers assembled in this volume bring the reader to the cutting edge of the potential practical applica tions of the network theory of the immune system.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 158 pp. Englisch. N° de réf. du vendeur 9783642706776
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