Synopsis
The international workshop on "Specificity and Function of Clonally Developing T Cells" was held at SchloG Rei- sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study- ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level. It was an attempt to provide an overview of the current research interests of groups working on (a) the developmen- tal potential of in vitro expanding primary T-cell clones (investigated using limiting dilution analysis) and cloned T -cell lines established in long-term culture; (b) the signals required for the expression of particular patterns of (func- tional and antigen receptor) phenotypes by T cells which are either freshly explanted in vitro, or maintained in vitro as cloned long-term lines; and (c) the generation of an MHC-restricted T-cell repertoire. In the study of thymocytes emphasis has shifted towards the presumably immature adult/embryonic subset(s) which is (are) devoid of subset-specific differentiation markers (L3T4, Lyt-2). Neither the signal requirement(s) for clonal expansion in vitro of these cells, nor their precursor role for any functional T -cell lineage are as yet unambiguously established. The multiple modes of human T-cell activation (e.g., via Tp44, T11, T3/Ti molecular complexes) were em- phasized by a number of presentations and raised the ques- tion of whether these different modes of activation induce different functional activities in individual T-cell clones.
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The international workshop on 'Specificity and Function of Clonally Developing T Cells' was held at SchloG Rei sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level. It was an attempt to provide an overview of the current research interests of groups working on (a) the developmen tal potential of in vitro expanding primary T-cell clones (investigated using limiting dilution analysis) and cloned T -cell lines established in long-term culture ; (b) the signals required for the expression of particular patterns of (func tional and antigen receptor) phenotypes by T cells which are either freshly explanted in vitro, or maintained in vitro as cloned long-term lines; and (c) the generation of an MHC-restricted T-cell repertoire. In the study of thymocytes emphasis has shifted towards the presumably immature adult/embryonic subset(s) which is (are) devoid of subset-specific differentiation markers (L3T4, Lyt-2). Neither the signal requirement(s) for clonal expansion in vitro of these cells, nor their precursor role for any functional T -cell lineage are as yet unambiguously established. The multiple modes of human T-cell activation (e.g., via Tp44, T11, T3/Ti molecular complexes) were em phasized by a number of presentations and raised the ques tion of whether these different modes of activation induce different functional activities in individual T-cell clones. 336 pp. Englisch. N° de réf. du vendeur 9783642711541
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Etat : New. Editor(s): Fleischer, Bernhard; Reimann, Jorg; Wagner, Hermann (Technische Universitat Munich, Germany). Series: Current Topics in Microbiology and Immunology. Num Pages: 332 pages, biography. BIC Classification: MJCM; MJCM1; MMFM. Category: (P) Professional & Vocational. Dimension: 244 x 170 x 17. Weight in Grams: 580. . 2011. Softcover reprint of the original 1st ed. 1986. Paperback. . . . . N° de réf. du vendeur V9783642711541
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. A: Development of T Lymphocytes in the Thymus.- Introductory Remarks.- Development of T Lymphocytes Within the Thymus and Within Thymic Nurse Cells. With 3 Figures.- Thymus Development.- Major Histocompatibility-Restricted Cytolytic T-Lymphocyte Precursors . N° de réf. du vendeur 5068739
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Taschenbuch. Etat : Neu. Specificity and Function of Clonally Developing T Cells | Bernhard Fleischer (u. a.) | Taschenbuch | xvi | Englisch | 2011 | Springer | EAN 9783642711541 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 106367013
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Specificity and Function of Clonally Developing T Cells
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The international workshop on 'Specificity and Function of Clonally Developing T Cells' was held at SchloG Rei sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level. It was an attempt to provide an overview of the current research interests of groups working on (a) the developmen tal potential of in vitro expanding primary T-cell clones (investigated using limiting dilution analysis) and cloned T -cell lines established in long-term culture ; (b) the signals required for the expression of particular patterns of (func tional and antigen receptor) phenotypes by T cells which are either freshly explanted in vitro, or maintained in vitro as cloned long-term lines; and (c) the generation of an MHC-restricted T-cell repertoire. In the study of thymocytes emphasis has shifted towards the presumably immature adult/embryonic subset(s) which is (are) devoid of subset-specific differentiation markers (L3T4, Lyt-2). Neither the signal requirement(s) for clonal expansion in vitro of these cells, nor their precursor role for any functional T -cell lineage are as yet unambiguously established. The multiple modes of human T-cell activation (e.g., via Tp44, T11, T3/Ti molecular complexes) were em phasized by a number of presentations and raised the ques tion of whether these different modes of activation induce different functional activities in individual T-cell clones.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch. N° de réf. du vendeur 9783642711541
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