The Role of Chromosomes in Cancer Biology - Couverture souple

Koller, Peo C. C.

Couverture souple

ISBN 10 : 3642806821 ISBN 13 : 9783642806827

Editeur : Springer, 2011

Synopsis

For many years Professor KOLLER has possessed an international reputation in the fields of cytogenetics and karyology, both in their fundamental aspects and in their relation to the problems of tumour causation, especially to the role of heteromromatin, and few men have made a greater contribution. The role of the mromosome complex in carcinogenesis has exerted a natural fascin- ation for many decades, but there can be little doubt of the great advances in know- ledge and understanding whim have accrued of recent years. Although it is probable that the key event in the inception of particular tumours resides in a delicate molec- ular rearrangement, and is hence undetectable by conventional microscopical methods, nevertheless a large proportion is accompanied by karyotypic variation and relatively gross changes in mromosomal number, order and arrangement, witness tlie discovery of the Philadelphia mromosome and its consequences. Further, any such manges in the mromosomal apparatus must inevitably be attended by profound repercussions in the cytoplasm with all that this must mean in protein synthesis and cellular behaviour.

A propos du livre

Présentation de l'éditeur

The Role of Chromosomes in Cancer Biology provides a description of the molecular organization and function of chromosomes and the consequences of chromosomal aberrations in human development. The book presents accounts on the structure and function of the chromosome; the cellular features of primary tumors and ascetic fluid; the cytological actions of radiation and drugs and their relevance to therapy. Developmental disorders caused by chromosomal anomalies; chromosome aneuploidy in human malignancies; and viral oncogenesis are discussed as well. The book will prove to be very insightful to those involved in cancer research, oncologists, cytologists, and molecular biologists.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 3642806821
• ISBN 13: 9783642806827
• Reliure: Broché
• Nombre de pages: 142
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne