Provided here is a comprehensive examination of the basic and clinical condition of three innovative and promising approaches to cancer therapy, which may support or even substitute chemotherapy: differentiation, immunomodulation, and inhibition of angiogenesis. Differentiation shouldnormalize neoplastic cells and make them compatible with the host. Its feasibility with retinoids, interferons, chemotherapeutic and other agents is discussed. Modulation by biological agents, cytotoxic effector cells and drugs is considered in attempts to boost endogenous antitumour defenses and/or to render neoplastic cells more susceptible to the immune attack of the host. Finally, the important aspect of interfering with tumour blood vessel development and function is taken into account. Consideringthe importance that chemotherapy has in cancer treatment and in view of a more and more integrated strategy, the relationship between the aforementioned approaches and chemotherapeutic agents and chemoresistance is treated in detail.
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Etat : New. Proceedings of the NATO Advanced Study Institute on Specific Approaches in Cancer Therapy: Differentiation, Immunomodulation and Angiogenesis held at Erice, Italy, October 17-27, 1992Provided here is a comprehensive examination of the basicand clinical . N° de réf. du vendeur 5072126
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Taschenbuch. Etat : Neu. Neuware - Provided here is a comprehensive examination of the basicand clinical condition of three innovative and promisingapproaches to cancer therapy, which may support or evensubstitute chemotherapy: differentiation, immunomodulationand inhibition of angiogenesis.Differentiation shouldnormalize neoplastic cells and makethem compatible with the host. Its feasibility withretinoids, interferons, chemotherapeutic and other agents isdiscussed. Modulation by biological agents, cytotoxiceffector cells and drugs is considered in attempts toboost endogenous antitumour defenses and/or to renderneoplastic cells more susceptible to the immune attack ofthe host. Finally, the important aspect of interfering withtumour blood vessel development and function is takeninto account.Consideringthe importance that chemotherapy has in cancertreatment and in view of a more and more integratedstrategy, the relationship between the aforementionedapproaches and chemotherapeutic agents and chemoresistanceis treated in detail. N° de réf. du vendeur 9783642846151
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