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Tetraspanin2 is a candidate for compensation of PLP functions - Couverture souple

Psol, Maryna

 
9783656513834: Tetraspanin2 is a candidate for compensation of PLP functions
Couverture souple
ISBN 10 : 365651383X ISBN 13 : 9783656513834
Editeur : Grin Verlag, 2014

Synopsis

Internship Report from the year 2012 in the subject Biology - Neurobiology, grade: 1,3, University of Göttingen (Max Plank Institute for Experimental Medicine / Department of Neurogenetics), language: English, abstract: Tetraspanin2 (Tspan2) is a member of the tetraspan/transmembrane4 superfamily restricted to the nervous system. The abundance of Tspan2 is low in physiological condition but increases greatly in myelin of PLP-deficient mice which may indicate its' compensatory functions. Our experiments show that Tspan2 has no effect on delay of myelination at P14; young and old mice lacking Tspan2 has the same g-ratio as wild type. However, the quantity of unhealthy axons and axonal swellings are higher in aged animals lacking both PLP and Tspan2 than in single PLP knockout. Furthermore, the absence of PLP causes the decrease in the number of axons and rise in axon diameter; lack of Tspan2 alone leads to decrease in quantity of 0.4-0.7 µm diameter axons in 40 weeks old mice. These findings point to a possible auxiliary role of Tspan2 in support of axonal transport and long-term axon preservation in PLP null condition.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de la quatrième de couverture

Internship Report from the year 2012 in the subject Biology - Neurobiology, grade: 1,3, University of Göttingen (Max Plank Institute for Experimental Medicine / Department of Neurogenetics), language: English, abstract: Tetraspanin2 (Tspan2) is a member of the tetraspan/transmembrane4 superfamily restricted to the nervous system. The abundance of Tspan2 is low in physiological condition but increases greatly in myelin of PLP-deficient mice which may indicate its¿ compensatory functions. Our experiments show that Tspan2 has no effect on delay of myelination at P14; young and old mice lacking Tspan2 has the same g-ratio as wild type. However, the quantity of unhealthy axons and axonal swellings are higher in aged animals lacking both PLP and Tspan2 than in single PLP knockout. Furthermore,the absence of PLP causes the decrease in the number of axons and rise in axon diameter; lack of Tspan2 alone leads to decrease in quantity of 0.4-0.7 µm diameter axons in 40 weeks old mice. These findings point to a possible auxiliary role of Tspan2 in support of axonal transport and long-term axon preservation in PLP null condition.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Grin Verlag
Date d'édition
2014
Langue
anglais
ISBN 10 
365651383X
ISBN 13 
9783656513834
Reliure
Broché
Nombre de pages
20
Coordonnées du fabricant
GRIN Publishing GmbH
info@grin.com

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München
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