Articles liés à "In vitro" Selection of rPrPc-binding RNA Molecules

"In vitro" Selection of rPrPc-binding RNA Molecules - Couverture souple

Anonymous

 
9783656823407: "In vitro" Selection of rPrPc-binding RNA Molecules

Synopsis

Internship Report from the year 2014 in the subject Chemistry - Bio-chemistry, grade: 1,0, Free University of Berlin (Institut für Chemie und Biochemie), course: Methodenmodul Nukleinsäuren, language: English, abstract: Aptamers can be considered as nucleic acid based analogues of monoclonar antibodies. These DNA or RNA molecules are characterized by a high affinity and selectivity to the target as well as a huge variety of possible targets, but feature significant advantages compared to antibodies such as the lack of immunogenicity and economic in vitro generation. The preparation of aptamers is based on systematic evolution (see figure 1). Cycles of selection and replication are conducted to narrow down a huge library to aptamers with the best binding properties to the target. In this experiment, an RNA aptamer to the rPrPc protein is selected in vitro. Since a whole SELEX procedures takes several weeks, only one selection cycle is done examplarily.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

Markus Giesecke wurde am 15. April 1979 in Regensburg geboren und ist seit 2011 als freiberuflicher Übersetzer und Dolmetscher für die Sprachen Deutsch, Englisch und Spanisch tätig. Für die englische Sprache ist er als Übersetzer vor dem Landgericht Regensburg öffentlich bestellt und allgemein vereidigt. Der Schwerpunkt seiner Tätigkeit liegt auf der Übersetzung und Beglaubigung von Urkunden, Zeugnissen, rechtlichen Dokumenten, Gerichtsurteilen, Jahresabschlüssen etc.

À propos de la quatrième de couverture

Internship Report from the year 2014 in the subject Chemistry - Bio-chemistry, grade: 1,0, Free University of Berlin (Institut für Chemie und Biochemie), course: Methodenmodul Nukleinsäuren, language: English, abstract: Aptamers can be considered as nucleic acid based analogues of monoclonar antibodies. These DNA or RNA molecules are characterized by a high affinity and selectivity to the target as well as a huge variety of possible targets, but feature significant advantages compared to antibodies such as the lack of immunogenicity and economic in vitro generation. The preparation of aptamers is based on systematic evolution (see figure 1). Cycles of selection and replication are conducted to narrow down a huge library to aptamers with the best binding properties to the target. In this experiment, an RNA aptamer to the rPrPc protein is selected in vitro. Since a whole SELEX procedures takes several weeks, only one selection cycle is done examplarily.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.