Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing - Couverture souple

Alborzinia, Hamed

Couverture souple

ISBN 10 : 3658101601 ISBN 13 : 9783658101602

Editeur : Springer Spektrum, 2015

Synopsis

Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

A propos du livre

À propos de l?auteur

Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Détails de l'édition

• Éditeur: Springer Spektrum
• Date d'édition: 2015
• Langue: anglais
• ISBN 10: 3658101601
• ISBN 13: 9783658101602
• Reliure: Broché
• Nombre de pages: 168
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne