Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.
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Matthias Würl wrote his Master's Thesis at the chair of Medical Physics at the Ludwig-Maximilians University Munich. He is now a PhD student at the same department, working on transmission imaging with laser-accelerated ions.
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Matthias Würlpresents two essential steps to implement offline PET monitoring of proton dosedelivery at a clinical facility, namely the setting up of an accurate MonteCarlo model of the clinical beamline and the experimental validation ofpositron emitter production cross-sections. In the first part, the field sizedependence of the dose output is described for scanned proton beams. Both theMonte Carlo and an analytical computational beam model were able to accuratelypredict target dose, while the latter tends to overestimate dose in normaltissue. In the second part, the author presents PET measurements of differentphantom materials, which were activated by the proton beam. The resultsindicate that for an irradiation with a high number of protons for the sake ofgood statistics, dead time losses of the PET scanner may become important andlead to an underestimation of positron-emitter production yields. 104 pp. Englisch. N° de réf. du vendeur 9783658131678
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