Engineering of Halogenases towards Synthetic Applications: Increasing the Thermostability and Investigations on a Marine Brominase Bmp5 - Couverture souple

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Minges, Hannah

 
9783658184094: Engineering of Halogenases towards Synthetic Applications: Increasing the Thermostability and Investigations on a Marine Brominase Bmp5
Couverture souple
ISBN 10 : 3658184094 ISBN 13 : 9783658184094
Editeur : Springer Spektrum, 2017

Synopsis

Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature’s toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place. 

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Hannah Minges, a Ph.D student at Bielefeld University, works on the optimization of tryptophan halogenases by means of directed evolution.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer Spektrum
Date d'édition
2017
Langue
anglais
ISBN 10 
3658184094
ISBN 13 
9783658184094
Reliure
Broché
Numéro d'édition
1
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
non disponible