Modelling Proteasome Dynamics in a Bayesian Framework - Couverture souple

Stübler, Sabine

Couverture souple

ISBN 10 : 3658201665 ISBN 13 : 9783658201661

Editeur : Springer Spektrum, 2017

Synopsis

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

A propos du livre

À propos de l?auteur

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Détails de l'édition

• Éditeur: Springer Spektrum
• Date d'édition: 2017
• Langue: anglais
• ISBN 10: 3658201665
• ISBN 13: 9783658201661
• Reliure: Broché
• Numéro d'édition: 1
• Nombre de pages: 112
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible