Cell and Tissue Engineering of Cartilage: Regulation of Chondrocyte by TGF-β and ECM-Proteins - Couverture souple

Khaghani, Seyed Ali (Behruz)

 
9783659113062: Cell and Tissue Engineering of Cartilage: Regulation of Chondrocyte by TGF-β and ECM-Proteins
Couverture souple
ISBN 10 : 3659113069 ISBN 13 : 9783659113062
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Cartilage cell (Chondrocyte) is embedded in the matrix (Lacunae) and has round shape in vivo. The in vitro monolayer culture of primary chondrocyte causes morphological change characterized as dedifferentiation. Transforming growth factor-beta (TGF-β), a cytokine superfamily, regulates cell function, including differentiation and proliferation. The effect of TGF-β1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was investigated in this work. A novel method was developed to isolate and purify the primary chondrocytes from knee joint of neonate Sprague-Dawley rat, and the effect of some supplementations such as hyaluronic acid and antibiotics were also investigated to provide the most appropriate condition for in vitro culture of chondrocyte cells.

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Présentation de l'éditeur

Cartilage cell (Chondrocyte) is embedded in the matrix (Lacunae) and has round shape in vivo. The in vitro monolayer culture of primary chondrocyte causes morphological change characterized as dedifferentiation. Transforming growth factor-beta (TGF-β), a cytokine superfamily, regulates cell function, including differentiation and proliferation. The effect of TGF-β1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was investigated in this work. A novel method was developed to isolate and purify the primary chondrocytes from knee joint of neonate Sprague-Dawley rat, and the effect of some supplementations such as hyaluronic acid and antibiotics were also investigated to provide the most appropriate condition for in vitro culture of chondrocyte cells.

Biographie de l'auteur

SA (Behruz) Khaghani, PhD (TE): Studied industry, mechanical and medical engineering in Turkey, Germany and United Kingdom respectively. He received PhD in cell and tissue engineering from University of Bradford and worked in industrial and large organisations for more than 18 years. He is currently a research fellow in cell and tissue engineering.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659113069
ISBN 13 
9783659113062
Reliure
Broché
Nombre de pages
212
Coordonnées du fabricant
non disponible
Personne responsable
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