Floating Strategie & Low Absorption Drug: Needs of Floating Drug Delivery System - Couverture souple

Siddiqui, Aslam; Tapar, Kiran; Pande, Shrikant

 
9783659117930: Floating Strategie & Low Absorption Drug: Needs of Floating Drug Delivery System
Couverture souple
ISBN 10 : 3659117935 ISBN 13 : 9783659117930
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Floating Drug Delivery Systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of Diltiazem hydrochloride. Drug absorption in the gastrointestinal tract is a highly variable processes and prolonging the gastric retention of dosage form via floating drug delivery system extends the time for drug absorption and ultimately increase bioavailability of drug. Diltiazem hydrochloride is a benzothiazepine-derivative calcium-channel blocker was chosen as a model drug due to its low oral bioavailability (30-40 %), short half-life (3 to 4 hrs), High frequency of dosing and low solubility at lower part of GI tract which makes it an appropriate candidate for a formulation in a sustained release floating drug delivery system, twice-a-day dosage form. The present study was aimed at designing a effervescent floating tablet of Diltiazem hydrochloride for controlled release of Diltiazem using different grades of Hydroxy propyl methyl cellulose such as HPMC K4M, HPMC K15M, HPMC K100M and Xanthan gum to achieve improved economy of tablet. Sodium bicarbonate and citric acid was used as a gas generating agent.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Floating Drug Delivery Systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of Diltiazem hydrochloride. Drug absorption in the gastrointestinal tract is a highly variable processes and prolonging the gastric retention of dosage form via floating drug delivery system extends the time for drug absorption and ultimately increase bioavailability of drug. Diltiazem hydrochloride is a benzothiazepine-derivative calcium-channel blocker was chosen as a model drug due to its low oral bioavailability (30-40 %), short half-life (3 to 4 hrs), High frequency of dosing and low solubility at lower part of GI tract which makes it an appropriate candidate for a formulation in a sustained release floating drug delivery system, twice-a-day dosage form. The present study was aimed at designing a effervescent floating tablet of Diltiazem hydrochloride for controlled release of Diltiazem using different grades of Hydroxy propyl methyl cellulose such as HPMC K4M, HPMC K15M, HPMC K100M and Xanthan gum to achieve improved economy of tablet. Sodium bicarbonate and citric acid was used as a gas generating agent.

Biographie de l'auteur

Asst.Professor Aslam Siddiqui has obtained his Master Degree in Pharmaceutics in 2010. Since then he has worked on different research topics in the field of novel drug delivery system. He is also the author of different research articles published in reputed journals and is a member of Association of Pharmaceutical Teachers of India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659117935
ISBN 13 
9783659117930
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
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