A Novel Approach For Controlled Drug Delivery - Microparticles: Formulation And Evaluation Of Microparticles For Controlled Delivery Of Tramadol Hydrochloride - Couverture souple

Patel, Shrujal; Teraiya, Sandip; Jayswal, Bhargav

 
9783659124488: A Novel Approach For Controlled Drug Delivery - Microparticles: Formulation And Evaluation Of Microparticles For Controlled Delivery Of Tramadol Hydrochloride
Couverture souple
ISBN 10 : 3659124486 ISBN 13 : 9783659124488
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Microparticles are one of the key novel drug delivery systems has been widely used to precisely modulate release rate. Microparticles based polymeric systems fabricated using suitable carrier has been extensively explored as an effective matrix for controlled and sustained release delivery of many drugs. With the controlled release systems, the rate of drug release matches the rate of drug elimination, and therefore the drug concentration is within the therapeutic window for the majority of the 24-hr period.The aim of this study was to prepare Eudragit microspheres containing Tramadol HCl by solvent evaporation method to achieve a controlled drug release profile. Investigation of the effect of various processing and formulation factors such as polymer type, drug: polymer ratio, stirring speed to obtain spherical particles. Then yield of production, shape, and mean particle size, particle size distribution, encapsulation efficiency, surface properties and release rate of drug from the microspheres were performed.

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Présentation de l'éditeur

Microparticles are one of the key novel drug delivery systems has been widely used to precisely modulate release rate. Microparticles based polymeric systems fabricated using suitable carrier has been extensively explored as an effective matrix for controlled and sustained release delivery of many drugs. With the controlled release systems, the rate of drug release matches the rate of drug elimination, and therefore the drug concentration is within the therapeutic window for the majority of the 24-hr period.The aim of this study was to prepare Eudragit microspheres containing Tramadol HCl by solvent evaporation method to achieve a controlled drug release profile. Investigation of the effect of various processing and formulation factors such as polymer type, drug: polymer ratio, stirring speed to obtain spherical particles. Then yield of production, shape, and mean particle size, particle size distribution, encapsulation efficiency, surface properties and release rate of drug from the microspheres were performed.

Biographie de l'auteur

Mr. Shrujal B. Patel is a young researcher who has earned degree of master of pharmacy specialization in pharmaceutics mainly deals with formulation and developement from Gujarat Technological University (Ahmedabad, Gujarat, INDIA).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659124486
ISBN 13 
9783659124488
Reliure
Broché
Nombre de pages
108
Coordonnées du fabricant
non disponible
Personne responsable
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