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Design & Developement of Floating Tablet of Tolperisone Hydrochloride: Gastroretentive drug delivery system - Couverture souple

Soni, Ravi; Patel, Mukesh; Patel, Natvarlal

 
9783659136061: Design & Developement of Floating Tablet of Tolperisone Hydrochloride: Gastroretentive drug delivery system
Couverture souple
ISBN 10 : 3659136069 ISBN 13 : 9783659136061
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.

Biographie de l'auteur

Ravikumar P. SoniShri B.M. Shah College of Pharmaceutical Education and Research. Education:I received my B. Pharm from Vidya bharti trust college of pharmacy in 2010 (with English), my M. Pharm from Gujarat Technological university in 2012 (with English).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659136069
ISBN 13 
9783659136061
Reliure
Broché
Nombre de pages
160
Coordonnées du fabricant
non disponible
Personne responsable
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