Articles liés à Accessibility to Construct Fused or Binary Heterocyclic...

Accessibility to Construct Fused or Binary Heterocyclic Compounds: Synthesis and Biological Evaluation of Novel Thiadiazole Derivatives - Couverture souple

Hamama, Wafaa S.; Gouda, Moustafa A.; Zoorob, Hanafi H.

 
9783659148989: Accessibility to Construct Fused or Binary Heterocyclic Compounds: Synthesis and Biological Evaluation of Novel Thiadiazole Derivatives
Couverture souple
ISBN 10 : 3659148989 ISBN 13 : 9783659148989
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

This book highlighted the methods used for the syntheses of thiadiazole compounds. The activity of thiadiazole and their synthetic importance were investigated. It also reported a theoretically study for the expected tautomeric behavior of 2-amino(imino)-1,3,4-thiadiazole to determine if it is acting either as amine or as semicyclic amidine. In this context, we reported herein the behavior of 2-aminothiadiazole towards some active reagents as a facile and convenient route to some fused or binary heterocyclic compounds containing a thiadiazole moiety. The methods of synthesis and the synthetic mechanisms of the aforementioned reactions were well presented and the structures of these compounds were assessed by analytical and spectral data. ABTS Antioxidant assay, Bleomycin-dependent DNA damage and antitumor activity methods were used for the evaluation of the biological activity of the investigated compounds.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book highlighted the methods used for the syntheses of thiadiazole compounds. The activity of thiadiazole and their synthetic importance were investigated. It also reported a theoretically study for the expected tautomeric behavior of 2-amino(imino)-1,3,4-thiadiazole to determine if it is acting either as amine or as semicyclic amidine. In this context, we reported herein the behavior of 2-aminothiadiazole towards some active reagents as a facile and convenient route to some fused or binary heterocyclic compounds containing a thiadiazole moiety. The methods of synthesis and the synthetic mechanisms of the aforementioned reactions were well presented and the structures of these compounds were assessed by analytical and spectral data. ABTS Antioxidant assay, Bleomycin-dependent DNA damage and antitumor activity methods were used for the evaluation of the biological activity of the investigated compounds.

Biographie de l'auteur

She has obtained her B.Sc. (1975), M.Sc. (1978) and Ph.D. (1983) in Organic Chemistry from Mansoura University. She is a reviewer for the Permanent Scientific Committee (Organic Chemistry, 2012). She worked in Um-El Koura University (1990-1996) and has obtained a postdoctoral fellowship (2009) at (DFG) Jacobs University.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659148989
ISBN 13 
9783659148989
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
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