Formulation and Evaluation of Colon Targeted Aceclofenac Tablet: Targeted drug delivery system - Couverture souple

Patel, Ashish V.; Patel, Mukesh R; Patel, Natubhai

 
9783659150982: Formulation and Evaluation of Colon Targeted Aceclofenac Tablet: Targeted drug delivery system
Couverture souple
ISBN 10 : 3659150983 ISBN 13 : 9783659150982
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The aim of the study was to develop and evaluate enteric‐coated matrix tablet of Aceclofenac for colonic delivery by exploiting prolonged release characteristics of HPMC K4M with pH dependent solubility property of a Eudragit S100. Extended release matrix tablet were prepared by direct compression of hydrophilic polymer HPMC and other ingredients. The pH dependent release was achieved by coating matrix tablet with Eudragit S100, soluble at pH 7. All the formulations of 32 factorial design (A1- A9) were evaluated for the physicochemical parameters and subjected to in vitro drug release in 0.1 N HCl for two hour, three hour in pH 5.2 Phosphate buffer then in pH 7.4 phosphate buffer up to 17 hrs. Multiple regression analysis, two way ANOVA followed by Tukey test were performed. Polynomial equations and response surface plots were generated for all dependent variables. It was observed that both the factors had significant effect on dependable variables (Q6, Q12, Q17 and n, k). The formulation A5 was most likely to provide targeting of aceclofenac in the colon owing to its minimal release of the drug in the first 5 hr and give release up to 17hr with 62.21 similarity factor.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The aim of the study was to develop and evaluate enteric‐coated matrix tablet of Aceclofenac for colonic delivery by exploiting prolonged release characteristics of HPMC K4M with pH dependent solubility property of a Eudragit S100. Extended release matrix tablet were prepared by direct compression of hydrophilic polymer HPMC and other ingredients. The pH dependent release was achieved by coating matrix tablet with Eudragit S100, soluble at pH 7. All the formulations of 32 factorial design (A1- A9) were evaluated for the physicochemical parameters and subjected to in vitro drug release in 0.1 N HCl for two hour, three hour in pH 5.2 Phosphate buffer then in pH 7.4 phosphate buffer up to 17 hrs. Multiple regression analysis, two way ANOVA followed by Tukey test were performed. Polynomial equations and response surface plots were generated for all dependent variables. It was observed that both the factors had significant effect on dependable variables (Q6, Q12, Q17 and n, k). The formulation A5 was most likely to provide targeting of aceclofenac in the colon owing to its minimal release of the drug in the first 5 hr and give release up to 17hr with 62.21 similarity factor.

Biographie de l'auteur

Ashish V. Patel M.Pharm:Gujarat Technological university, India

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659150983
ISBN 13 
9783659150982
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
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