Normal and Binding Mode Analysis of Breast Cancer Resistance Protein: Structural Bioinformatics of BCRP - Couverture souple

Kumar, Prasanth; Patel, Saumya; Pandya, Himanshu

 
9783659153129: Normal and Binding Mode Analysis of Breast Cancer Resistance Protein: Structural Bioinformatics of BCRP
Couverture souple
ISBN 10 : 3659153125 ISBN 13 : 9783659153129
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.

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Présentation de l'éditeur

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.

Biographie de l'auteur

S. Prasanth Kumar, a budding researcher in Department of Bioinformatics, Gujarat University. A recipient of DST INSPIRE fellowship from Ministry of Science and Technology, Government of India. He has been awarded Young Scientist Award twice. He's actively involved in research areas: molecular modeling, structural bioinformatics & sequence analysis.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659153125
ISBN 13 
9783659153129
Reliure
Broché
Nombre de pages
104
Coordonnées du fabricant
non disponible
Personne responsable
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