Synthesis of Trioxanes as Antimalarial: A Text book of Antimalarial Drugs - Couverture souple

Gautam, Girendra Kumar; Gautam, Payal

Couverture souple

ISBN 10 : 3659154261 ISBN 13 : 9783659154263

Editeur : LAP Lambert Academic Publishing, 2012

Synopsis

The work of this book provides us to understand that trioxanes can be a better alternative medication for Malaria. Malaria is a major parasitic disease of the tropics, affecting around 300–500 million people of which more than one million die each year. Peroxide group, present in the form of 1, 2, 4-trioxane, is essential for the anti-malarial activity. A series of 1,2,4 trioxane derivative synthesized by treating p-chloroacetophenone with ethyl 2-bromoacetate to give ethyl 3-(4-chloro phenyl)-3-hydroxy butanoate which on dehydration, yield (Z)-ethyl 3-(4-chloro phenyl) but-2 enoate. On reduction yield (Z)-ethyl 3-(4-chloro phenyl) prop-1-en-1-ol. Further on photo oxygenation it yield 3-(4-chlorophenyl)-2 hydroperoxybut-3-en-1-ol, which on condensation with ketones to give the final product. The structures of synthesized compound were confirmed on the basis of their spectral data and elemental analysis. Compounds were evaluated for antimalarial activity against Plasmodium yoelii and compared with standard drug. The final product derivatives are potent in antimalarial activity.

A propos du livre

À propos de l'auteur

Girendra Kumar Gautam, M-Pharm, PhD (Thesis Submitted), in Pharmaceutical Chemistry is serving as a Assistant Professor in the area of Academics and Research in Public Sector for welfare of society. He is the Author of several Paper published in reputed journals and is a member of different national and international working groups.

Détails de l'édition

• Éditeur: LAP Lambert Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3659154261
• ISBN 13: 9783659154263
• Reliure: Broché
• Nombre de pages: 124
• Coordonnées du fabricant: non disponible
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