Development and Evaluation of Proliposomes-Based Drug Delivery Systems: Proliposomes-Based Drug Delivery Systems - Couverture souple

Gupta, Sandeep; Ahirwar, Dheeraj; Pandey, Aditya Nath

 
9783659160981: Development and Evaluation of Proliposomes-Based Drug Delivery Systems: Proliposomes-Based Drug Delivery Systems
Couverture souple
ISBN 10 : 3659160989 ISBN 13 : 9783659160981
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.

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Présentation de l'éditeur

The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.

Biographie de l'auteur

(M. Pharm, Phd)School of Pharmacy, Chouksey Engineering College.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659160989
ISBN 13 
9783659160981
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
Personne responsable
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