Articles liés à EFFECT OF PAPAVERINE ON LIPID PEROXIDATION IN SICKLE...

EFFECT OF PAPAVERINE ON LIPID PEROXIDATION IN SICKLE CELL ANAEMIA: Ca Channel Inhibitor As Plausible Hbs Anti-sickling Agent: Effect Of Papaverine On Lipid Peroxidation Of Sickle Cells - Couverture souple

Njoku, Ugochi Olivia; Agu, Chidozie Victor; Lynda, Iheruo

 
9783659163678: EFFECT OF PAPAVERINE ON LIPID PEROXIDATION IN SICKLE CELL ANAEMIA: Ca Channel Inhibitor As Plausible Hbs Anti-sickling Agent: Effect Of Papaverine On Lipid Peroxidation Of Sickle Cells
Couverture souple
ISBN 10 : 3659163678 ISBN 13 : 9783659163678
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Sickle cell anaemia is an inherited genetic disorder characterized by an abnormal haemoglobin (HbS) which results in the polymerization of the red cells under certain physiological conditions leading to sickling. This work was carried out to find the effect of papaverine (an alkaloid) as a possible drug for the management of sickle cell anaemia. Electrophoresis was carried out on various blood samples – AA, AS, and SS to confirm their genotype. Haematological parameters, serum calcium level and lipid peroxidation assays were carried out. The result of the haematological studies reveal that the sickle cell patient had an increase in red blood cell, haemoglobin count, erythrocyte sedimentation rate, and a decrease in platelet count and when compared to HbAA and HbAS. Serum calcium levels show an increased level in the sickle cell patients compared to the other genotypes. The result of the lipid peroxidation assay show that HbSS has the highest value in the lipid peroxidation product. After incubation with papaverine, the lipid peroxidation level decreased in all the groups. Thus, Papaverine could be a possible drug for the management of sickle cell anaemia.

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Présentation de l'éditeur

Sickle cell anaemia is an inherited genetic disorder characterized by an abnormal haemoglobin (HbS) which results in the polymerization of the red cells under certain physiological conditions leading to sickling. This work was carried out to find the effect of papaverine (an alkaloid) as a possible drug for the management of sickle cell anaemia. Electrophoresis was carried out on various blood samples – AA, AS, and SS to confirm their genotype. Haematological parameters, serum calcium level and lipid peroxidation assays were carried out. The result of the haematological studies reveal that the sickle cell patient had an increase in red blood cell, haemoglobin count, erythrocyte sedimentation rate, and a decrease in platelet count and when compared to HbAA and HbAS. Serum calcium levels show an increased level in the sickle cell patients compared to the other genotypes. The result of the lipid peroxidation assay show that HbSS has the highest value in the lipid peroxidation product. After incubation with papaverine, the lipid peroxidation level decreased in all the groups. Thus, Papaverine could be a possible drug for the management of sickle cell anaemia.

Biographie de l'auteur

The Authors, Njoku Ugochi Olivia, Agu Chidozie Victor and Iheruo Lynda are staff and students of the Department of Biochemistry University of Nigeria Nsukka

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659163678
ISBN 13 
9783659163678
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
Personne responsable
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