Self Emulsifying Drug Delivery System: Dissolution enhancement of Ibuprofen using Response surface methodology - Couverture souple

Hossain, Md. Ismail; Akhter, Sadika

 
9783659174384: Self Emulsifying Drug Delivery System: Dissolution enhancement of Ibuprofen using Response surface methodology
Couverture souple
ISBN 10 : 3659174386 ISBN 13 : 9783659174384
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Solubility is considered as a great problem for Ibuprofen hence a solubility enhancing technique, Self-emulsifying drug delivery system (SEDDS), was considered to be developed for Ibuprofen. Capmul PG 8 was used as a co-solvent. As surfactant, hydrophilic surfactant Cremophor EL was considered. A fixed amount of Ibuprofen was added with fixed amount of excipients. Capmul PG8 showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Cremophor EL also showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. A 3-level factorial design was carried out to optimize the formulation. The optimized formula contains 24.10 mg Capmul PG8 and 71.02 mg Cremophor EL which releases 27.78%, 44.6% and 74.24% ibuprofen at the mentioned time interval. The present study shows that the Capmul PG8 and Cremophor EL have increased the release profile of capsule Ibuprofen. This attempt, therefore, delivers an alternative strategy in drug product formulation for poorly water soluble drugs. Pharmaceutical technologists, Pharmacists will find it a fruitful approach specially those working on drug delivery.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Solubility is considered as a great problem for Ibuprofen hence a solubility enhancing technique, Self-emulsifying drug delivery system (SEDDS), was considered to be developed for Ibuprofen. Capmul PG 8 was used as a co-solvent. As surfactant, hydrophilic surfactant Cremophor EL was considered. A fixed amount of Ibuprofen was added with fixed amount of excipients. Capmul PG8 showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Cremophor EL also showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. A 3-level factorial design was carried out to optimize the formulation. The optimized formula contains 24.10 mg Capmul PG8 and 71.02 mg Cremophor EL which releases 27.78%, 44.6% and 74.24% ibuprofen at the mentioned time interval. The present study shows that the Capmul PG8 and Cremophor EL have increased the release profile of capsule Ibuprofen. This attempt, therefore, delivers an alternative strategy in drug product formulation for poorly water soluble drugs. Pharmaceutical technologists, Pharmacists will find it a fruitful approach specially those working on drug delivery.

Biographie de l'auteur

I have completed Bachelor of pharmacy from Gono University and Master of Science in Pharmaceutical Technology from University of Asia Pacific. I have Long been involved in research work and six publications have been published in international journals. Currently, working in a research project on antioxidant agents from plant sources.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659174386
ISBN 13 
9783659174384
Reliure
Broché
Nombre de pages
88
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne