Cell adhesion behavior on molecularly engineered surfaces: Mechanisms of Cell/Surface Interaction - Couverture souple

Cai, Ning

 
9783659190391: Cell adhesion behavior on molecularly engineered surfaces: Mechanisms of Cell/Surface Interaction
Couverture souple
ISBN 10 : 365919039X ISBN 13 : 9783659190391
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Effective attachment of cells on biomaterials is one important requirement in designing engineered tissue substitute. Better understanding of biophysical responses of adherent cells is of great importance in optimizing biomaterial surface for tissue engineering applications. In this work, poly(lactic acid) (PLA) and carbon nanotubes (CNT), were surface-modified with extracellular matrix (ECM) proteins to improve their compatibility. The results of adhesion dynamics of porcine esophageal fibroblasts (PEFs) on ECM protein-immobilized PLA and CNT monolayer demonstrate the different biophysical responses of PEFs on unmodified and ECM protein-modified biomaterial surfaces. ECM protein immobilization effectively promotes adhesion of PEFs to biomaterials surfaces. In addition, it is found that functional blocking of β1 integrin impaires cell-fibronectin interactions. Adhesion strength is tightly correlated to focal adhesion density, which is explained by peeling and fracture models. Furthermore, Weibull distribution is proved to satisfactorily describe cell adhesion strength in adherent cell population.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
365919039X
ISBN 13 
9783659190391
Reliure
Broché
Nombre de pages
220
Coordonnées du fabricant
non disponible
Personne responsable
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