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Post-translational modifications and associations in the IGF system - Couverture souple

Nedić, Olgica

 
9783659192296: Post-translational modifications and associations in the IGF system
Couverture souple
ISBN 10 : 3659192295 ISBN 13 : 9783659192296
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

The incidence of cancer, diabetes mellitus, cardiovascular and some other diseases continues to increase and there are still no sufficiently successive healing and preventive strategies. Insulin-like growth factors (IGFs) play important roles during entire life and, depending on the biochemical pathway in which they are involved, they may be regarded as growth factors, hormones or cytokines. IGFs exert their functions after binding to specific receptors and their availability is regulated by IGF-binding proteins. Altered activity in the IGF signaling pathways is connected with diseases, but data are controversial as both beneficial and harmful effects of IGFs were recorded. Traditional approaches to study biochemical pathways, mostly based on the synthesis and clearance rates, are not sufficient. Post-translational protein modifications and associations with other biomolecules may represent an intermediate level of control, which deserves more attention. This book provides an overview of the post-translational events which affect the IGF system, offering experimental data to document structural and functional changes which, as a final consequence, have altered IGF activity.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The incidence of cancer, diabetes mellitus, cardiovascular and some other diseases continues to increase and there are still no sufficiently successive healing and preventive strategies. Insulin-like growth factors (IGFs) play important roles during entire life and, depending on the biochemical pathway in which they are involved, they may be regarded as growth factors, hormones or cytokines. IGFs exert their functions after binding to specific receptors and their availability is regulated by IGF-binding proteins. Altered activity in the IGF signaling pathways is connected with diseases, but data are controversial as both beneficial and harmful effects of IGFs were recorded. Traditional approaches to study biochemical pathways, mostly based on the synthesis and clearance rates, are not sufficient. Post-translational protein modifications and associations with other biomolecules may represent an intermediate level of control, which deserves more attention. This book provides an overview of the post-translational events which affect the IGF system, offering experimental data to document structural and functional changes which, as a final consequence, have altered IGF activity.

Biographie de l'auteur

Principal researcher in the Institute for the Application of Nuclear Energy, University of Belgrade, Serbia. PhD in Biochemistry. Research field: insulin and insulin-like growth factors in metabolic control associated with specific nutritional regime, physical activity, physiological status (ageing, pregnancy) and diseases.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659192295
ISBN 13 
9783659192296
Reliure
Broché
Nombre de pages
156
Coordonnées du fabricant
non disponible
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