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Bioinformatic Analysis of cDNA Clones from Human Y Chromosome: An original research on male specific regions of human Y chromosome using bioinformatics based approach - Couverture souple

Chattopodhyay, Koushik

 
9783659195105: Bioinformatic Analysis of cDNA Clones from Human Y Chromosome: An original research on male specific regions of human Y chromosome using bioinformatics based approach
Couverture souple
ISBN 10 : 3659195103 ISBN 13 : 9783659195105
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Maleness in humans is determined by the presence or absence of the Y chromosome, which encodes the SRY (sex-determining region of Y) gene necessary for testis development. The human Y chromosome contains a large sex and species-specific heterochromatic block on the distal end of its long arm. There may be some genes hitherto unexplored in the heterochromatic region of the human Y chromosome. The present study investigates the significance of the distal Yq heterochromatic block of human Y chromosome by experimental and computational methods. The present study was carried out in two parts. One part included sequencing of the 10-cDNA clones. The other part which is also the main part of this book included bioinformatics analysis of the sequences of the clones. Sequencing of the clones was done by PCR-Sequencing. Bioinformatics analysis was done using several programs such as, NCBI BLAST, CLUSTAL W, GeneSplicer, NatGene2, Genscan etc. Bio-informatics analysis of the experimental results showed a clear evidence of transcription from both strands by both the cDNA clones found by our lab in the distal heterochromatic block of the long arm of human Y chromosome.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Maleness in humans is determined by the presence or absence of the Y chromosome, which encodes the SRY (sex-determining region of Y) gene necessary for testis development. The human Y chromosome contains a large sex and species-specific heterochromatic block on the distal end of its long arm. There may be some genes hitherto unexplored in the heterochromatic region of the human Y chromosome. The present study investigates the significance of the distal Yq heterochromatic block of human Y chromosome by experimental and computational methods. The present study was carried out in two parts. One part included sequencing of the 10-cDNA clones. The other part which is also the main part of this book included bioinformatics analysis of the sequences of the clones. Sequencing of the clones was done by PCR-Sequencing. Bioinformatics analysis was done using several programs such as, NCBI BLAST, CLUSTAL W, GeneSplicer, NatGene2, Genscan etc. Bio-informatics analysis of the experimental results showed a clear evidence of transcription from both strands by both the cDNA clones found by our lab in the distal heterochromatic block of the long arm of human Y chromosome.

Biographie de l'auteur

Dr. Koushik Chattopadhyay (previously Chatterjee) obtained his M.Sc. (biotechnology) from India and Ph.D. in human genetics from University of Cape Town. He has worked in various reputed research institutes in different fields of human genetics. He has authored several original research and review articles in international peer-reviewed journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659195103
ISBN 13 
9783659195105
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
Personne responsable
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