Early Prediction of Preeclampsia: Predictive value of urinary albumin, collagen-IV in subsequent development of preeclampsia - Couverture souple

Fatema, Kaneez

 
9783659198953: Early Prediction of Preeclampsia: Predictive value of urinary albumin, collagen-IV in subsequent development of preeclampsia
Couverture souple
ISBN 10 : 3659198951 ISBN 13 : 9783659198953
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Pre-eclampsia (PE) is a multisystem disorder of unknown cause, is unique to human pregnancy. Over the last two decades many biochemical factors have been selected to detect their predictive value in PE. More recent studies have claimed that increased urinary levels of collagen IV can predict early diabetic nephropathy. This study was done to explore whether elevated urinary concentration of collagen IV in early pregnancy is potentially a more sensitive predictor of PE than microalbumin (MA). Among 119 study subjects, the sensitivity of ACR for PE was 80%, specificity 49.54%, PPV 12.69% and NPV 96.42%. In case of collagen IV, the sensitivity was found to be 70%, specificity 52.5%, PPV 11.5% and NPV 94.8%. Since detection of urinary collagen IV is a relatively costly test compared to MA rather it does not give any added advantage, its use may not be advocated to predict PE in cases of pregnancy. This study took place in developing nations like Bangladesh, where maternal and fetal deaths from preeclampsia are greatest and tertiary care facilities are limited. Prediction of PE might allow a reduction of the worldwide mortality and morbidity.

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Présentation de l'éditeur

Pre-eclampsia (PE) is a multisystem disorder of unknown cause, is unique to human pregnancy. Over the last two decades many biochemical factors have been selected to detect their predictive value in PE. More recent studies have claimed that increased urinary levels of collagen IV can predict early diabetic nephropathy. This study was done to explore whether elevated urinary concentration of collagen IV in early pregnancy is potentially a more sensitive predictor of PE than microalbumin (MA). Among 119 study subjects, the sensitivity of ACR for PE was 80%, specificity 49.54%, PPV 12.69% and NPV 96.42%. In case of collagen IV, the sensitivity was found to be 70%, specificity 52.5%, PPV 11.5% and NPV 94.8%. Since detection of urinary collagen IV is a relatively costly test compared to MA rather it does not give any added advantage, its use may not be advocated to predict PE in cases of pregnancy. This study took place in developing nations like Bangladesh, where maternal and fetal deaths from preeclampsia are greatest and tertiary care facilities are limited. Prediction of PE might allow a reduction of the worldwide mortality and morbidity.

Biographie de l'auteur

At present, Assistant Professor (Obst & Gyne), Faridpur Medical College and Hospital, Bangladesh. She passed MBBS from Sir Salimullah Medical College and achieved MS from BSMMU, Dhaka. She has several publications in the respective subjects. Her main interest is academic research in the field of obstetrics & gynecology.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659198951
ISBN 13 
9783659198953
Reliure
Broché
Nombre de pages
68
Éditeur
Chowdhury T. A., Ali Liaquat
Coordonnées du fabricant
non disponible
Personne responsable
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