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Designing an Inhibitor for AAC(6’)-Ii: Fragment-based Drug Design using SAR by NMR - Couverture souple
Synopsis
Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6’-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6’)-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6’) inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group.
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À propos de l'auteur
Eric Habib first got his bachelor's degree in biochemistry at McGill University in 2008. He later changed to more applied research, obtaining his master's degree from McGill's chemistry department in 2013 in the groups of Profs Auclair and Mittermaier. He is now pursuing studies in material science at Université de Montréal with Prof Julian Zhu.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
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Designing an Inhibitor for AAC(6')-Ii
Edité par
LAP LAMBERT Academic Publishing Mär 2014, 2014
ISBN 10 : 3659199842
ISBN 13 : 9783659199844
Neuf
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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6')-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6') inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group. 156 pp. Englisch. N° de réf. du vendeur 9783659199844
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Designing an Inhibitor for AAC(6 )-Ii
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Couverture souple
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Habib EricEric Habib first got his bachelor s degree in biochemistry at McGill University in 2008. He later changed to more applied research, obtaining his master s degree from McGill s chemistry department in 2013 in the groups of P. N° de réf. du vendeur 5139072
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Designing an Inhibitor for Aac(6')-II
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Designing an Inhibitor for Aac(6')-II
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
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Neuf
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Etat : New. Print on Demand pp. 156 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. N° de réf. du vendeur 132679078
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Designing an Inhibitor for Aac(6')-II
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
ISBN 10 : 3659199842
ISBN 13 : 9783659199844
Neuf
Couverture souple
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Designing an Inhibitor for AAC(6¿)-Ii : Fragment-based Drug Design using SAR by NMR
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LAP LAMBERT Academic Publishing, 2014
ISBN 10 : 3659199842
ISBN 13 : 9783659199844
Neuf
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6')-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6') inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group. N° de réf. du vendeur 9783659199844
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Designing an Inhibitor for AAC(6')-Ii
Edité par
LAP LAMBERT Academic Publishing Mär 2014, 2014
ISBN 10 : 3659199842
ISBN 13 : 9783659199844
Neuf
Taschenbuch
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6')-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6') inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group.OmniScriptum SRL, Str. Armeneasca 28/1, office 1, 2012 Chisinau 156 pp. Englisch. N° de réf. du vendeur 9783659199844
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Designing an Inhibitor for AAC(6')-Ii | Fragment-based Drug Design using SAR by NMR
Edité par
LAP LAMBERT Academic Publishing, 2014
ISBN 10 : 3659199842
ISBN 13 : 9783659199844
Neuf
Taschenbuch
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Taschenbuch. Etat : Neu. Designing an Inhibitor for AAC(6')-Ii | Fragment-based Drug Design using SAR by NMR | Eric Habib | Taschenbuch | 156 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783659199844 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 105354772
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