Design and in vitro Evaluation of Sustained Release Dosage Forms: Containing Metformin Hydrochloride - Couverture souple

Vasireddy, Suneel Kumar; Chaurasia, Sandhya; Sharma, Anshuli

 
9783659202056: Design and in vitro Evaluation of Sustained Release Dosage Forms: Containing Metformin Hydrochloride
Couverture souple
ISBN 10 : 3659202053 ISBN 13 : 9783659202056
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Metformin matrix and gastro retentive tablets formulations were prepared with different compositions. Finally, one optimized formula for each, matrix and gastro retentive, were selected and studied in detail. The effect of formulation variables namely, process of manufacturing, different excipients, different polymers, and concentration of polymer were studied. Metformin release was inversely proportional to the polymer concentration. Drug release from the developed formulations was independent of pH of the release medium but dependent on the agitational intensity, hardness of tablet, and surface area of tablet. Metformin release from both developed matrix and gastro retentive formulations follows first order. The manufacturing procedure was found to be reproducible and formulations were stable after one month of accelerated stability studies.

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Présentation de l'éditeur

Metformin matrix and gastro retentive tablets formulations were prepared with different compositions. Finally, one optimized formula for each, matrix and gastro retentive, were selected and studied in detail. The effect of formulation variables namely, process of manufacturing, different excipients, different polymers, and concentration of polymer were studied. Metformin release was inversely proportional to the polymer concentration. Drug release from the developed formulations was independent of pH of the release medium but dependent on the agitational intensity, hardness of tablet, and surface area of tablet. Metformin release from both developed matrix and gastro retentive formulations follows first order. The manufacturing procedure was found to be reproducible and formulations were stable after one month of accelerated stability studies.

Biographie de l'auteur

Suneel Kumar Vasireddy completed his M pharmacyfrom andhra university Visakhapatnam (A.P) He iscurrently working as group leader at Ranbaxylaboratories ltd. Gurgaon (H.R.)

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659202053
ISBN 13 
9783659202056
Reliure
Broché
Nombre de pages
164
Coordonnées du fabricant
non disponible
Personne responsable
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