Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines: Chalcones, Pyrazolines, Isoxazolines, Isoxazoles derived from 3-Acetyl Quinolines: Antimicrobial and Cytotoxcity Studies - Couverture souple

Vijayakumar, V.; Sarveswari, S.

 
9783659202148: Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines: Chalcones, Pyrazolines, Isoxazolines, Isoxazoles derived from 3-Acetyl Quinolines: Antimicrobial and Cytotoxcity Studies
Couverture souple
ISBN 10 : 3659202142 ISBN 13 : 9783659202148
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Quinoline heterocycles found to have diverse biological activities and 3-functionalised quinolines are important intermediates for the synthesis of various quinoline derivatives. 3-acetyl-4-hydroxy-quinolin-2(1H)-one and 6-chloro-3-acetyl-4-phenyl-2-methyl quinoline were chosen as intermediates for the synthesis of some novel quinoline derivatives. In particular, only a few methods are available for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-one, which involve either two step or multistep reaction protocols. In the present work, a rapid, efficient and one pot procedure for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-ones has been developed both by conventional and microwave assisted synthesis. The 3-acetyl quinolines were converted into chalcones which in turn converted to quinoline-3-yl pyrazolines and quinoline-3-yl isoxazolines and a few into 3-(2, 4-substitutedstyryl)isoxazolo[4,5-c]quinolin-4(5H)-ones. These compounds were explored for their anti-microbial and cyctotoxicity studies.

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Présentation de l'éditeur

Quinoline heterocycles found to have diverse biological activities and 3-functionalised quinolines are important intermediates for the synthesis of various quinoline derivatives. 3-acetyl-4-hydroxy-quinolin-2(1H)-one and 6-chloro-3-acetyl-4-phenyl-2-methyl quinoline were chosen as intermediates for the synthesis of some novel quinoline derivatives. In particular, only a few methods are available for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-one, which involve either two step or multistep reaction protocols. In the present work, a rapid, efficient and one pot procedure for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-ones has been developed both by conventional and microwave assisted synthesis. The 3-acetyl quinolines were converted into chalcones which in turn converted to quinoline-3-yl pyrazolines and quinoline-3-yl isoxazolines and a few into 3-(2, 4-substitutedstyryl)isoxazolo[4,5-c]quinolin-4(5H)-ones. These compounds were explored for their anti-microbial and cyctotoxicity studies.

Biographie de l'auteur

Associate Professor in Organic Chemistry Division at VIT University, Vellore completed his Ph.D at Gandhigram University, Dindigul in Nitrogen Heterocycles. Focusing on the synthesis of various heterocycles and exploring their applications in medicinal field and published more than 130 articles in various international journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659202142
ISBN 13 
9783659202148
Reliure
Broché
Nombre de pages
248
Coordonnées du fabricant
non disponible
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