Articles liés à Enhancement of solubilization & bioavailability...

Enhancement of solubilization & bioavailability of poorly soluble drug: Enhancement of aqueous solubility - Couverture souple

Chaudhary, Amit; Nagaich, Upendra; Agrawal, D.K.

 
9783659211577: Enhancement of solubilization & bioavailability of poorly soluble drug: Enhancement of aqueous solubility
Couverture souple
ISBN 10 : 3659211575 ISBN 13 : 9783659211577
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The aim of this work is to improve the solubilization and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parenterally, topically and orally administered solutions. Physical modifications techniques like media milling/ nanocrystal technology, cryogenic technology, supercritical fluid process, modification of the crystal habit, complexation, micellar technologies, chemical modifications etc.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The aim of this work is to improve the solubilization and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parenterally, topically and orally administered solutions. Physical modifications techniques like media milling/ nanocrystal technology, cryogenic technology, supercritical fluid process, modification of the crystal habit, complexation, micellar technologies, chemical modifications etc.

Biographie de l'auteur

Mr. Amit Chaudhary is currently working as Asst. Prof. of Pharmaceutics in BIT-School of Pharmacy, Meerut (U.P.) India. He is the core member of Health Quest Foundation, Chandigarh. He is serving as Secretary of NES Educational society, Meerut (U.P.). He is associated with Indian Pharmaceutical Association (IPA).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659211575
ISBN 13 
9783659211577
Reliure
Broché
Nombre de pages
52
Coordonnées du fabricant
non disponible
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