Articles liés à Human Fidgetin and Its Functions in Mitosis and Cell...

Human Fidgetin and Its Functions in Mitosis and Cell Migration: Characterization of Human Fidgetin and Its Functions During Mitosis and Cell Migration - Couverture souple

Mukherjee, Suranjana; Sharp, David

 
9783659212888: Human Fidgetin and Its Functions in Mitosis and Cell Migration: Characterization of Human Fidgetin and Its Functions During Mitosis and Cell Migration
Couverture souple
ISBN 10 : 3659212881 ISBN 13 : 9783659212888
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Microtubule is an essential component of the cytoskeleton required for several important cellular processes such as cell division, cellular morphogenesis and migration. In cells, functions of microtubules are tightly regulated by additional microtubule-associated proteins called MAPs. Fidgetin is a microtubule-associated protein, which influences several microtubule based cellular processes by regulating microtubule dynamics. Fidgetin is a microtubule severing and depolymerizing enzyme and possibility by utilizing these properties it regulates mitosis and cellular migration. Both of these processes are extremely important during cell proliferation and tissue morphogenesis. Defects in these processes may lead to malignant transformation and developmental defects including neurodegenerative disease, as the formation of neuronal processe is in many ways a modified form of cell migration. Notably, Fidgetin mutation causes developmental and behavioral defects in mice. This study might lead ways to the molecular etiology of these diseases and develop effective therapeutic strategies for their treatment.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Microtubule is an essential component of the cytoskeleton required for several important cellular processes such as cell division, cellular morphogenesis and migration. In cells, functions of microtubules are tightly regulated by additional microtubule-associated proteins called MAPs. Fidgetin is a microtubule-associated protein, which influences several microtubule based cellular processes by regulating microtubule dynamics. Fidgetin is a microtubule severing and depolymerizing enzyme and possibility by utilizing these properties it regulates mitosis and cellular migration. Both of these processes are extremely important during cell proliferation and tissue morphogenesis. Defects in these processes may lead to malignant transformation and developmental defects including neurodegenerative disease, as the formation of neuronal processe is in many ways a modified form of cell migration. Notably, Fidgetin mutation causes developmental and behavioral defects in mice. This study might lead ways to the molecular etiology of these diseases and develop effective therapeutic strategies for their treatment.

Biographie de l'auteur

Suranjana Mukherjee has done her B.Sc in Chemisty and M.Sc in Biochemistry from University of Calcutta, India. She obtained her PhD from Albert Einstein College of Medicine, New York in January 2011. Currently she is a postdoctoral researcher at the Department of Cell Biology and Physiology in Washington University School of Medicine in St. Louis.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659212881
ISBN 13 
9783659212888
Reliure
Broché
Nombre de pages
96
Coordonnées du fabricant
non disponible
Personne responsable
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