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Lectin Conjugated Gastro-Retentive Delivery System: Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori - Couverture souple

Jain, Sunil K.; Jangdey, Manmohan Singh

 
9783659213779: Lectin Conjugated Gastro-Retentive Delivery System: Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori
Couverture souple
ISBN 10 : 3659213772 ISBN 13 : 9783659213779
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

An optimized Ethylcellulose microspheres of Clarithromycin were successfully prepared using emulsion/ solvent evaporation method and Con-A was successfully attached to the microspheres using carbodiimide method. Attachment of lectin to the Ethylcellulose microspheres significantly increased the mucoadhesiveness and also controls the release of Clarithromycin in simulated GI fluids. Conjugation aggregation assay suggesting that the lectin can be able to target in the treatment of Helicobacter pylori infection in peptic ulcer disease. Gamma scintigraphy study suggesting that Con-A lectin conjugated Ethylcellulose microspheres have gained considerable attention due to their ability to adhere to the mucus layer, as well as to release the drug in a controlled manner. It is concluded that designed targeted delivery system could possibly increases the bioavailability of Clarithromycin and treated the gastric ulcer in an effective manner.

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Présentation de l'éditeur

An optimized Ethylcellulose microspheres of Clarithromycin were successfully prepared using emulsion/ solvent evaporation method and Con-A was successfully attached to the microspheres using carbodiimide method. Attachment of lectin to the Ethylcellulose microspheres significantly increased the mucoadhesiveness and also controls the release of Clarithromycin in simulated GI fluids. Conjugation aggregation assay suggesting that the lectin can be able to target in the treatment of Helicobacter pylori infection in peptic ulcer disease. Gamma scintigraphy study suggesting that Con-A lectin conjugated Ethylcellulose microspheres have gained considerable attention due to their ability to adhere to the mucus layer, as well as to release the drug in a controlled manner. It is concluded that designed targeted delivery system could possibly increases the bioavailability of Clarithromycin and treated the gastric ulcer in an effective manner.

Biographie de l'auteur

Dr. SUNIL K. JAIN, Assistant Professor (Pharmaceutics), SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur, INDIA

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659213772
ISBN 13 
9783659213779
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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