Antiinflammatory Styryl Derivatives: Design, Synthesis, and Biology: Benzylidene Acetone Oxime Ether Derivatives - Couverture souple

El-Gamal, Mohammed; Bayomi, Said

 
9783659218200: Antiinflammatory Styryl Derivatives: Design, Synthesis, and Biology: Benzylidene Acetone Oxime Ether Derivatives
Couverture souple
ISBN 10 : 3659218200 ISBN 13 : 9783659218200
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

This book explains design, synthesis, and pharmacological properties of a series of substituted benzylidene acetone oxime ether derivatives from the corresponding oxime derivatives. The newly synthesized compounds were investigated in vivo for their antiinflammatory activities using carrageenin-induced rat paw oedema model. Among the compounds examined, compounds IVe and Vd showed the highest activity, nearly equivalent to that of the standard drug diclofenac sodium. Hence, they were screened for their analgesic activities using acetic acid-induced writhing model in mice and also, their ulcerogenic effects were studied. Compound Vd was found to possess significant antiinflammatory and analgesic activities with negligible ulcerogenic effect. In silico studies have been carried out.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659218200
ISBN 13 
9783659218200
Reliure
Broché
Nombre de pages
140
Coordonnées du fabricant
non disponible
Personne responsable
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