Brain Development: Roles of Transient Neurons in Corpus Callosum Formation and Guidance - Couverture souple

Niquille, Mathieu

 
9783659218491: Brain Development: Roles of Transient Neurons in Corpus Callosum Formation and Guidance
Couverture souple
ISBN 10 : 3659218499 ISBN 13 : 9783659218491
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The brain is a main center for control over the other organs in all vertebrate. It is responsible for higher-order functions like processing environmental stimuli or language and it is divided in two hemispheres. In order to achieve such tasks, the right and left sides need to be connected and the corpus callosum is the major bridge (over 200 mio. of axons) channeling and coordinating information between these two hemispheres. Previous works have shown that glial cells (non-neuronal brain cells) found at the midline of the brain are essential for guiding the projections from one side to the other side. We found that two populations of neuronal cells are also required for the proper formation of the corpus callosum and for the guidance of interhemispheric axons during embryonic development. Similar mechanisms could occur in humans and observations of human pathologies with defects in corpus callosum formation suggest that these neurons could be involved. This work thus gives new insights into how neurons together with their glial partners have the ability to shape the corpus callosum, a potential process for guidance in other brain regions.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The brain is a main center for control over the other organs in all vertebrate. It is responsible for higher-order functions like processing environmental stimuli or language and it is divided in two hemispheres. In order to achieve such tasks, the right and left sides need to be connected and the corpus callosum is the major bridge (over 200 mio. of axons) channeling and coordinating information between these two hemispheres. Previous works have shown that glial cells (non-neuronal brain cells) found at the midline of the brain are essential for guiding the projections from one side to the other side. We found that two populations of neuronal cells are also required for the proper formation of the corpus callosum and for the guidance of interhemispheric axons during embryonic development. Similar mechanisms could occur in humans and observations of human pathologies with defects in corpus callosum formation suggest that these neurons could be involved. This work thus gives new insights into how neurons together with their glial partners have the ability to shape the corpus callosum, a potential process for guidance in other brain regions.

Biographie de l'auteur

Mathieu Niquille has achieved a Phd degree in Neurosciences in 2011 in the field of Developmental Neurobiology. His work focused on embryonic brain wiring and guidance and was the matter of a first author publication in PLOS Biology and a co-author publication in PLOS Genetics. He has then extended its researchs in Psychatric Neurobiology.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659218499
ISBN 13 
9783659218491
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
Personne responsable
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