Comparative Assessment Of The Q/c Measurements Of Ofloxacin Tablets: Introduction, Concept, Methods And Results - Couverture souple

Babu, Dinesh

 
9783659219092: Comparative Assessment Of The Q/c Measurements Of Ofloxacin Tablets: Introduction, Concept, Methods And Results
Couverture souple
ISBN 10 : 3659219096 ISBN 13 : 9783659219092
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The main purpose of the study is to evaluate some quality control parameters to compare the quality, safety, and efficacy of five brands of ofloxacin tablets available in the Indian market. The physicochemical parameters and assay of the five brands of ofloxacin tablets were assessed through the evaluation of uniformity of tablet weight, friability, hardness, disintegration, and assay of active ingredients according to established methods. Weight variation of the tablets proved statistically that all of the tablets were in accordance to the required limits that is not more then ±5% deviations. Dissolution test was carried out; none had potency less than 85% within 60minutes the required specification, not less than Q+5%. Pharmaceutical assay was carried out none had potency less than the required specification (90.00% - 100.00%). The dissolution rate and disintegration time were determined in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes. All brands complied with the official specification for uniformity of weight, friability, and disintegration and dissolution in both Simulated gastric fluid and simulated intestinal fluid.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The main purpose of the study is to evaluate some quality control parameters to compare the quality, safety, and efficacy of five brands of ofloxacin tablets available in the Indian market. The physicochemical parameters and assay of the five brands of ofloxacin tablets were assessed through the evaluation of uniformity of tablet weight, friability, hardness, disintegration, and assay of active ingredients according to established methods. Weight variation of the tablets proved statistically that all of the tablets were in accordance to the required limits that is not more then ±5% deviations. Dissolution test was carried out; none had potency less than 85% within 60minutes the required specification, not less than Q+5%. Pharmaceutical assay was carried out none had potency less than the required specification (90.00% - 100.00%). The dissolution rate and disintegration time were determined in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes. All brands complied with the official specification for uniformity of weight, friability, and disintegration and dissolution in both Simulated gastric fluid and simulated intestinal fluid.

Biographie de l'auteur

Dinesh Babu G. is M.pharmacy - pharmaceutics graduate from M.E.S.college of pharmacy at Rajiv Gandhi University of Health Sciences, Bangalore.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659219096
ISBN 13 
9783659219092
Reliure
Broché
Nombre de pages
60
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne