Articles liés à Development of Sustained Release Tablets of Eplerenone:...

Development of Sustained Release Tablets of Eplerenone: Effect of Cellulose and Natural Polymers - Couverture souple

Reddy, Sunil; Katakam, Vinay Kumar; Yamsani, Madhusudan Rao

 
9783659222887: Development of Sustained Release Tablets of Eplerenone: Effect of Cellulose and Natural Polymers
Couverture souple
ISBN 10 : 3659222887 ISBN 13 : 9783659222887
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The objective of this work was to develop of a suitable SR tablet formulation of Eplerenone and to study the effect of polymers such as HPMC K4M, HPMC K15M, NaCMC, Guar gum, Xanthan gum and Karaya gum on drug release. Profile and to get an optimized formulation. Eplerenone binds to the mineralo corticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). It has a half life of 4 hrs. When dose is missing it may cause nocturnal attack, so attention was made to develop the Sustained release tablets of Eplerenone. The purpose of controlled release systems is to maintain drug concentration in the blood or in target tissues at a desired value as long as possible. In other words, they are able to exert a control on the drug release rate and duration. In the market only IR tablets of Eplerenone were available which are costly. So there is a need to formulate SRMT of Eplerenone to reduce the cost and increase the patient compliance.

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À propos de l'auteur

Dr. Sunil Reddy is working as Associate Prof. at St.Peter's College of Pharmacy, Warangal, Andhrapradesh, India. He has completed B.Pharm, M.Pharm and Ph.D.from Kakatiya University, Warangal, Andhrapradesh, India. He has 10 International and 08 National Journals and contributed several book chapters. He has 20 research presentations.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659222887
ISBN 13 
9783659222887
Reliure
Broché
Nombre de pages
68
Coordonnées du fabricant
non disponible
Personne responsable
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