Development of Carvedilol Phosphate sustained release tablet: Anti-hypertensive agent:Carvedilol phosphate - Couverture souple

Kumar, Uttom; Harun-Or-Rashid, Mr.; Rouf, Dr. A. S. Shamsur

Couverture souple

ISBN 10 : 3659228451 ISBN 13 : 9783659228452

Editeur : LAP Lambert Academic Publishing, 2012

Synopsis

The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS > PEG 6000 > Poloxamer 188.

A propos du livre

À propos de l'auteur

Uttom Kumar completed his M. Pharm. from the Department of Pharmaceutical Technology, University of Dhaka, Bangladesh. He conducted his thesis under the supervision of Prof. Dr. A. S. Shamsur Rouf, a renowned scientist. Currently Uttom is a member of Dr. Rouf’s research lab where Mr. Harun-Or-Rashid is an associate researcher.

Détails de l'édition

• Éditeur: LAP Lambert Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3659228451
• ISBN 13: 9783659228452
• Reliure: Broché
• Nombre de pages: 156
• Coordonnées du fabricant: non disponible
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